2017 Fiscal Year Final Research Report
Study on the role of regulatory B cells and their therapeutic application to acute and autoimmune pancreatitis
| Project/Area Number |
15K09053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 制御性B細胞 / 急性膵炎 / 自己免疫性膵炎 / 細胞移入 |
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| Outline of Final Research Achievements |
To clarify the role of regulatory B cells in the development of acute pancreatitis, we studied a murine model of experimental pancreatitis induced by cerulein and lipopolysaccharide. There was no difference in the severity of pancreatitis between wild type and B cell-deficient mice. Pancreatitis deteriorated in CD19-deficient mice that lack regulatory B cells. However, administration of interleukin 10-producing B10 cells ameliorated pancreatitis in CD19-deficient mice. In contrast with wild type mice, CD19-deficient mice developed autoimmune pancreatitis by administration of poly I:C. Taken together, regulatory B cells are supposed to be involved in the suppression of pancreatitis, suggesting the usefulness of them in the treatment of pancreatitis.
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| Free Research Field |
消化器内科学
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