Termination mechanisms of atrial fibrillation by rotor-based ablation and establishment of patient-tailored atrial fibrillation therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09077
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo (2017); Nagoya University (2015-2016)
• Principal Investigator: YAMAZAKI MASATOSHI 東京大学, 大学院工学系研究科(工学部), 特任研究員(主任) (30627328)
• Co-Investigator(Kenkyū-buntansha): 佐久間 一郎 東京大学, 大学院工学系研究科(工学部), 教授 (50178597) ; 本荘 晴朗 名古屋大学, 環境医学研究所, 准教授 (70262912) ; 芦原 貴司 滋賀医科大学, 医学部, 講師 (80396259)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 心房細動 / ローター / アブレーション

Outline of Final Research Achievements

Atrial fibrillation (AF) is the most common sustained atrial arrhythmia. Recently, several physicians have demonstrated the feasibility of localizing fibrillatory reentrant sources (rotor) with a 64-spine catheter-enabled electrogram phase analysis. Preliminary results with this approach have shown substantial improvement of the ablation outcome. Regardless of the ablation strategy, however, the mechanisms by which electrogram-based point ablation may succeed or fail are unknown. Here, we employed advanced optical mapping techniques to examine AF dynamics before and after rotor-based ablation for AF. In 2 animals AF terminated, while in the remainder 5 animals the post-ablation maximum region of dominant frequency domains relocated to far region. These results suggest that ablation of meandering pathway may be better strategy than rotor-based ablation of AF.

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