Risk prediction for sudden cardiac death by quantitative analysis of fragmented QRS and J wave using differentiation of signal addition

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Okayama University
• Principal Investigator: Morita Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (50322227)
• Co-Investigator(Kenkyū-buntansha): 杉山 洋樹 岡山大学, 医学部, 客員研究員 (20726137)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 心臓性突然死 / 致死的不整脈 / 遺伝性不整脈 / QRS棘波 / 早期再分極 / J波

Outline of Final Research Achievements

Fragmented QRS (fQRS) represents intraventricular conduction abnormality due to myocardial injury and fibrosis. fQRS will result in arrhythmogeneic substrate and cardiac dysfuncitn. J wave is also electrophysiological abnormality that can promote lethal arrhythmias. We have evaluated existence of fQRS and J wave in various heart diseases. Our published data were adopted for “J-wave syndromes expert consensus conference report” endorsed by APHRS, EHRA, HRS and SOLAECE and “Guidelines for diagnosis and management of inherited arrhythmias; JCS 2017” by Japanese Circulation Society.

Free Research Field

心臓突然死を来す遺伝性不整脈、重症不整脈、心筋症などを中心に研究を行っている。