Elucidation of compensatory mechanism against excessive free water excretion by aquaretic diuretics in heart failure

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09086
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kyushu University
• Principal Investigator: Hiasa Ken-ichi 九州大学, 大学病院, 助教 (00380452)
• Co-Investigator(Kenkyū-buntansha): 肥後 太基 九州大学, 医学研究院, 助教 (10457426)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 利尿薬による過度の除水 / 利尿薬抵抗性心不全 / 水利尿薬

Outline of Final Research Achievements

In patients with drug-resistant heart failure, it was found that the increase in fractional excretion of potassium (FEK) after tolvaptan administration was significantly correlated with poor prognosis. As tolvaptan is a drug that, unlike other natriuretic drugs, has no effect on potassium excretion, increase in potassium excretion rate in the kidney after tolvaptan administration is thought to reflect renal blood flow reduction or activation of renin / angiotensin / aldosterone system. FEK was considered to be a convenient and useful indicator that it can find unexpectedly excessive free water removal at an early stage after tolvaptan administration.

Free Research Field

心不全、心エコー、救急