Investigation for clinical impact of serum Klotho level in tissue characterization of coronary artery plaque

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09087
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagasaki University
• Principal Investigator: KOGA Seiji 長崎大学, 病院(医学系), 助教 (00398158)
• Co-Investigator(Kenkyū-buntansha): 池田 聡司 長崎大学, 医歯薬学総合研究科(医学系), 講師 (10336159) ; 前村 浩二 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 石灰化 / 冠動脈疾患 / 動脈硬化 / 血管内イメージング / 慢性腎臓病

Outline of Final Research Achievements

Klotho protein plays a crucial role in calcium/phosphate metabolism. However, physiological significance of serum α-Klotho has not yet been elucidated in detail. We analyzed coronary artery calcification in 75 patients with stable angina pectoris who underwent percutaneous coronary intervention following intravascular ultrasound (IVUS). The main outcome measure was the calcium index which was calculated from IVUS-derived total calcium length, lesion length, and maximal calcium arc. Serumα-Klotho levels correlated significantly and positively with estimated glomerular filtration rate (eGFR), and negatively with fibroblast growth factor 23 (FGF23) and calcium index. Multivariate regression analysis showed that serum α-Klotho was a significant independent factor associated with calcium index. In conclusion, an independent, inverse relationship was observed between serum α-Klotho level and coronary calcification in patients with stable angina pectoris.

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