Impact of serum sulfatide level or micro RNA on coronary plaque vulnerability or restenosis post percutaneous coronary intervention

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Dokkyo Medical University
• Principal Investigator: Taguchi Isao 獨協医科大学, 医学部, 教授 (80316570)
• Co-Investigator(Kenkyū-buntansha): 小松 孝昭 獨協医科大学, 医学部, 講師 (10597537) ; 井上 晃男 獨協医科大学, 医学部, 教授 (20168454) ; 中原 志朗 獨協医科大学, 医学部, 准教授 (70383081) ; 京ヶ島 守 日本薬科大学, 薬学部, 教授 (50225091)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 冠動脈疾患 / カテーテル治療 / 再狭窄

Outline of Final Research Achievements

The present study demonstrated that a balloon alone percutaneous coronary intervention (PCI) using drug coated balloon or ‘Stent-less PCI’ exhibited equivalent effects compared to PCI with drug eluting stents in coronary artery disease patients. After ‘Stent-less PCI’, anti-thrombotic agents can be reduced safely, because stent thrombosis or neo-atherosclerosis can be prevented. Therefore, coronary events and bleeding events will be prevented simultaneously and long term prognosis can be improved. In patients received ‘Stent-less PCI’ who plan to undergo non-cardiac surgeries, anti-thrombotic agents can be discontinued safely, and bleeding complications can be reduced. Additionally, when a patient after ‘Stent-less PCI’ will need coronary artery bypass grafting (CABG) in the future, there will be no coronary stent that might interfere in CABG.
‘Stent-less PCI’ should be performed in the patients whose coronary artery lesions can be dilated optimally only with balloon.

Free Research Field

医歯薬学、臨床循環器内科学