2017 Fiscal Year Final Research Report
Effect of metabolic syndrome on the remodeling and thrombosis formation of atrial fibrillation
| Project/Area Number |
15K09104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | メタボリック症候群 / 心房細動 / リモデリング / 血栓形成 / 脂肪浸潤 |
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| Outline of Final Research Achievements |
To investigate the impact of obesity/metabolic syndrome on electrophysiologic and anatomical AF substrates, 15 dogs were divided into three groups. High-fat diet and rapid atrial pacing for 4-8 weeks (MetS-AF group, n=5), Rapid atrial pacing for 4-8 weeks with normal diet (AF group, n=5), and Noarmal diet without rapid atrial pacing (control group, n=5). Body weight was increased significantly in MetS-AF group than in AF and control groups. During electrophysiologic study, ERP of the left atrium (LA)/pulmonary veins (PVs) were shorter in MetS-AF group than AF group and control group. Histological examination showed extent of fatty infiltration with a small fibrotic change in epicardial LA increased in the MetS-AF group compared to AF and control groups. Shortening of LA/PVs-ERP was correlated with the extent of fatty infiltration. Our data suggest that fatty infiltration of the LA in the MetS-AF group plays an important role in the pathogenesis of AF.
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| Free Research Field |
医歯薬学
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