2017 Fiscal Year Final Research Report
Investigation of the possible involvement of varicella-herpes zoster virus in cardiac sarcoidosis
| Project/Area Number |
15K09107
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | Osaka Medical College |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
石坂 信和 大阪医科大学, 医学部, 教授 (20270879)
藤田 修一 大阪医科大学, 医学部, 講師 (80722628)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | サルコイドーシス / 病因 / 帯状疱疹 / Propionibacterium acnes / 網羅的検索 |
|---|
| Outline of Final Research Achievements |
In this study, serological, pathophysiological, and molecular biological studies were performed to investigate the possible involvement of varicella-herpes zoster virus (VZV) and Propionibacterium acnes (P. acnes). Comprehensive analyses of granuloma tissues for the presence of 174 different viruses and 75 bacteria/fungi revealed no genes of these pathogens in the tissues . These findings suggest that active pathogens such as VZV and P. acnes are unlikely to be present in granuloma in patients with sarcoidosis.
|
| Free Research Field |
循環器内科学
|
