Establishment of novel managemnt for inoperable chronic thromboembolic pulmonary hypertension patinets

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09116
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: Sugimura Koichiro 東北大学, 大学病院, 講師 (60375079)
• Co-Investigator(Kenkyū-buntansha): 佐藤 公雄 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: CTEPH / BPA / 予後 / 血行動態 / 酸素化 / 代謝 / 画像評価

Outline of Final Research Achievements

We have achieved some certain results as follows.
1)4D-MRI imaging visualizes drastic change in vortex flow after BPA. Eur Heart J. 2015 Jul 1;36(25):1630.2)Multiple beneficial effects of BPA. Circ J. 2016.3)BPA improved oxygenation with a resultant decrease in intrapulmonary shunt. Circ J. 2016 80(10):2227-34. 4)We report a significantly higher prevalence of schizophrenia in patients with CTEPH than in those with pulmonary arterial hypertension (PAH) and the general population. Int J Cardiol. 2016;207:363-4.5)BPA improves biventricular functions and in CTEPH. Circ J. 2016;80(6):1470-7.6)Dual-energy CT to estimate clinical severity of CTEPH. Eur J Radiol. 2016;85:1574-80. 7)Plasma levels of TAFI are elevated in patients with CTEPH and are correlated with resistance to clot lysis in those patients. Arterioscler Thromb Vasc Biol. 2016;36:1293-301.8)The beneficial haemodynamic effects of BPA persist for years with resultant good long-term prognosis. Eur Heart J 2017 38:3152-3159.

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