Biomarker for cardiovascular disease risk based on quantification of DNA damage

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Hiroshima University
• Principal Investigator: Ishida Mari 広島大学, 医歯薬保健学研究科(医), 准教授 (30359898)
• Co-Investigator(Kenkyū-buntansha): 石田 隆史 福島県立医科大学, 医学部, 教授 (40346482)
• Co-Investigator(Renkei-kenkyūsha): TASHIRO SATOSHI 広島大学, 原爆放射線医科学研究所, 教授 (20243610)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: DNA損傷 / 動脈硬化 / 老化 / 危険因子

Outline of Final Research Achievements

The relationship between the pathology of various diseases and the DNA damage repair system has been clarified. The contribution of cardiovascular risk factors such as diabetes, hypertension, smoking, dyslipidemia, and aging to disease onset depends on the difference in response of individual's cells. We investigated whether the amount of DNA double strand breaks (DSBs) in the mononuclear cells may be an inclusive biomarker for the risks. We found that the amount of DSBs in the mononuclear cell correlates with a specific risk factor rather than the presence of arteriosclerosis. This is important in contributing to the stratification of risk, and we will continue to study the mechanism while increasing the number of cases.

Free Research Field

循環器内科学