Ionic Mechanism of Chronic Inflammation and Myocardial Disorders: The Role of Inflammation Responsive Orai3 Channel

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Akita University
• Principal Investigator: Ito Hiroshi 秋田大学, その他部局等, 特任教授 (10232464)
• Co-Investigator(Kenkyū-buntansha): 渡邊 博之 秋田大学, 医学(系)研究科(研究院), 教授 (80323145) ; 飯野 健二 秋田大学, 医学部, 講師 (30400485)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 慢性心不全 / 心筋障害 / 炎症 / Orai

Outline of Final Research Achievements

Inflammation is the base condition of chronic heart failure.　Recently, Orai3 was identified as an arachidonic-acid (AA)-responsive Ca channel, which play a role in the ion mechanism of inflammation. This study was aimed to clarify the role of Orai3 in the inflammatory mechanism in heart failure. In the experiment using knockout mice and Ca flow analysis, we showed that Orai3 participate in the condition of heart failure. Further, AA and nitric oxide (NO), which are known to be key signal of inflammation, are related in this mechanism. These data may lead to a development of novel therapy of heart failure in the future.

Free Research Field

循環器内科学