2017 Fiscal Year Final Research Report
Ryanodine receptor-targeting therapy for heart failure and lethal arrhythmia
| Project/Area Number |
15K09142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山本 健 山口大学, 大学院医学系研究科, 教授 (50363122)
矢野 雅文 山口大学, 大学院医学系研究科, 教授 (90294628)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ryanodine receptor / heart failure / arrhythmia / dantrolene |
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| Outline of Final Research Achievements |
We investigated (1) whether transverse aortic constriction (TAC)-induced pressure overload caused Ca2+ leak through cardiac ryanodine receptor (RyR2), and (2) whether chronic administration of dantrolene, a RyR2 stabilizer, inhibited the cardiomyocyte hypertyrophy and dysfunction by stopping the Ca2+leak.The aberrant Ca2+ leak through RyR2 was observed even in the compensated pressure-overloaded heart. Dantrolene restores the cardiomyocyte dysfunction and inhibits the cardiomyocyte hypertrophy by inhibiting the aberrant Ca2+ leak through RyR2. Targeting RyR2 treatment by dantrolene may be a novel strategy for pressure-overloaded hypertrophy.
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| Free Research Field |
循環器科
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