糖尿病を合併した虚血性心不全に対する治療戦略

2015 Fiscal Year Research-status Report

• Project/Area Number: 15K09143
• Research Institution: Fukushima Medical University
• Principal Investigator: 竹石 恭知 福島県立医科大学, 医学部, 教授 (40272067)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: myocardial infarction / heart failure / diabetes mellitus / HMGB1

Outline of Annual Research Achievements

心筋にのみ選択的に HMGB1 遺伝子を高発現したトランスジェニックマウス (HMGB1-TG) と野生型マウス（WT）にストレプトゾトシンを腹腔内に投与した。２週後に血糖値を測定し、血糖値が 400～500 mg/dL を越え、糖尿病が発症していることを確認した。次いで、両群のマウスの冠動脈左前下行枝を結紮し、心筋梗塞を作成した。心筋梗塞作成１週後に採血し、フローサイトメトリーで末梢血中の GFP 陽性の骨髄由来血管内皮前駆細胞（EPC） 数をカウントした。２週後に心エコーで心機能評価を行った後、マウスをサクリファイスし心重量、肺重量、心筋梗塞サイズ、梗塞周囲部 (border zone) の capillary density、GFP 陽性の骨髄由来血管内皮細胞数を測定した。
糖尿病状態では、非糖尿病時とは異なり、GFP 陽性の骨髄由来 EPC 数、心重量、肺重量、心筋梗塞サイズ、border zone の capillary density、GFP 陽性の骨髄由来血管内皮細胞数に HMGB1-TG と WT マウスで差を認めなかった。
HMGB1 による骨髄由来血管内皮細胞数の増加と血管新生の促進が糖尿病マウスでは認められなかったため、血中のdipeptidyl peptidase-IV (DPP4)活性と HMGB1 濃度を測定した。DPP4 活性は糖尿病マウスで上昇しており、心筋梗塞後の HMGB1 濃度の上昇は見られなかった。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

糖尿病状態で心筋梗塞を作成し、心筋梗塞サイズ、border zone の capillary density、骨髄由来血管内皮細胞数を HMGB1-TG と WT マウスで比較検討できた。血中の DPP4 活性は糖尿病マウスで上昇しており、心筋梗塞作成後の血中 HMGB1 濃度の上昇は見られなかった。この結果から、stromal cell-derived factor-1 といった造血幹細胞因子と同様に、HMGB1 が DPP4 の基質となり分解され、その作用が減弱されたことが示唆された。

Strategy for Future Research Activity

DPP4 阻害薬を投与下に、HMGB1-TG と WT マウスにストレプトゾトシンを投与し、心筋梗塞を作成する。DPP4 阻害薬投与により、血中 HMGB1 濃度が回復し、border zone の capillary density、骨髄由来血管内皮細胞数の増加と心筋梗塞サイズの縮小が認められるかを検討する。

Research Products

• [Journal Article] The association between circulating anti-angiogenic isoform of vascular endothelial growth factor and clinical profiles in patients with peripheral artery disease (2016)
  • Author(s): Akihiko Sato, Akiomi Yoshihisa, Tetsuro Yokokawa, Takeshi Shimizu, Yuichi Nakamura, Tomofumi Misaka, Masashi Kamioka, Takashi Kaneshiro, Satoshi Suzuki, Hiroyuki Kunii, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: International Journal of Cardiology Volume: 207 Pages: 368-369
  • DOI: 10.1016/j.ijcard.2016.01.189
  • Peer Reviewed
• [Journal Article] Predominance of abdominal visceral adipose tissue reflects the presence of aortic valve calcification (2016)
  • Author(s): Masayoshi Oikawa, Takashi Owada, Hiroyuki Yamauchi, Tomofumi Misaka, Hirofumi Machii, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: BioMed Research International Volume: 2016 Pages: 2174657
  • DOI: 10.1155/2016/2174657
  • Peer Reviewed / Open Access
• [Journal Article] Plasma leves of receptor for advanced glycation end-products and high-mobility group box 1 in patients with pulmonary hypertension (2016)
  • Author(s): Satoshi Suzuki, Kazuhiko Nakazato, Koichi Sugimoto, Akiomi Yoshihisa, Takayoshi Yamaki, Hiroyuki Kunii, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: International Heart Journal Volume: 57 Pages: 230-240
  • DOI: 10.1536/ihj.15-188
  • Peer Reviewed / Open Access
• [Journal Article] Intravascular ultrasound predictors of acute side branch occlusion in coronary artery bifurcation lesions just after single stent crossover (2016)
  • Author(s): Nobuo Sakamoto, Yasuto Hoshino, Hiroyuki Mizukami, Koichi Sugimoto, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: Catheterization and Cardiovascular Interventions Volume: 87 Pages: 243-250
  • DOI: 10.1002/ccd.26021
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of cardiovascular mortality in the Great East Japan and the Great Hanshin-Awaji Earthquakes -A large-scale data analysis of death certificates- (2015)
  • Author(s): Takegami M, Miyamoto Y, Yasuda S, Nakai M, Nishimura K, Ogawa H, Hirata K, Toh R, Morino Y, Nakamura M, Takeishi Y, Shimokawa H, Naito H
  • Journal Title: Circulation Journal Volume: 79 Pages: 1000-1008
  • DOI: 10.1253/circj.CJ-15-0223
  • Peer Reviewed / Open Access
• [Journal Article] Comparisons of prognostic factors between young and elderly patients with chronic heart failure (2015)
  • Author(s): Sato T, Yamauchi H, Kanno Y, Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Geriatrics and Gerontology International Volume: 15 Pages: 435-442
  • DOI: 10.1111/ggi.12293
  • Peer Reviewed
• [Journal Article] Deficiency of the long pentraxin PTX3 promoted neointimal hyperplasia after vascular injury (2015)
  • Author(s): Ishino M, Shishido T, Suzuki S, Katoh S, Sasaki T, Funayama A, Netsu S, Hasegawa H, Honda S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Pages: 372-378
  • DOI: 10.5551/jat.26740
  • Peer Reviewed / Open Access
• [Journal Article] Impact of peripheral artery disease on prognosis in hospitalized heart failure patients (2015)
  • Author(s): Nakamura Y, Kunii H, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Circulation Journal Volume: 79 Pages: 785-793
  • DOI: 10.1253/circj.CJ-14-1280
  • Peer Reviewed / Open Access
• [Journal Article] High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis (2015)
  • Author(s): Narumi T, Shishido T, Otaki Y, Kadowaki S, Honda Y, Funayama A, Honda S, Hasegawa H, Kinoshita D, Yokoyama M, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Tanaka A, Woo C, Abe J, Takeishi Y, Kubota I
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 82 Pages: 1-12
  • DOI: 10.1016/j.yjmcc.2015.02.018
  • Peer Reviewed / Open Access
• [Journal Article] Impact of sleep-disordered breathing on myocardial damage and metabolism in patients with chronic heart failure (2015)
  • Author(s): Miyata M, Yoshihisa A, Yamauchi H, Owada T, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart and Vessels Volume: 30 Pages: 318-324
  • DOI: 10.1007/s00380-014-0479-6
  • Peer Reviewed
• [Journal Article] High mobility group box 1 promotes angiogenesis from bone marrow-derived endothelial progenitor cells after myocardial infarction (2015)
  • Author(s): Nakamura Y, Suzuki S, Shimizu T, Miyata M, Shishido T, Ikeda K, Saitoh S, Kubota I, Takeishi Y
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Pages: 570-581
  • DOI: 10.5551/jat.27235
  • Peer Reviewed / Open Access
• [Journal Article] Mental health problems among undergraduates in Fukushima, Tokyo, and Kyoto after the March 11 Tohoku Earthquake (2015)
  • Author(s): Ishikawa S, Motoya R, Sasagawa S, Takahashi T, Okajima I, Takeishi Y, Essau CA
  • Journal Title: Tohoku Journal of Experimental Medicine Volume: 236 Pages: 155-122
  • DOI: 10.1620/tjem.236.115
  • Peer Reviewed / Open Access
• [Journal Article] Beneficial effects of positive airway pressure therapy for sleep-disordered breathing in heart failure patients with preserved left ventricular ejection fraction (2015)
  • Author(s): Yoshihisa A, Suzuki S, Yamauchi H, Sato T, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Clinical Cardiology Volume: 38 Pages: 413-421
  • DOI: 10.1002/clc.22412
  • Peer Reviewed / Open Access
• [Journal Article] Endogenous carbon monoxide concentration in blood elevates in acute coronary syndrome of nonsmoker population (2015)
  • Author(s): Kobayashi A, Mizukami H, Sakamoto N, Yamaki T, Kunii H, Nakazato K, Takeishi Y
  • Journal Title: Fukushima Journal of Medical Science Volume: 61 Pages: 72-78
  • DOI: 10.5387/fms.2015-1
  • Peer Reviewed / Open Access
• [Journal Article] Increased prevalence of atrial fibrillation after the Great East Japan Earthquake: Results from the Fukushima Health Management Survey (2015)
  • Author(s): Suzuki H, Ohira T, Takeishi Y, Hosoya M, Yasumura S, Satoh H, Kawasaki Y, Takahashi A, Sakai A, Ohtsuru A, Kobashi G, Ozasa K, Yamashita S, Kamiya K, Abe M, for the Fukushima Health Management Survey Group
  • Journal Title: International Journal of Cardiology Volume: 198 Pages: 102-105
  • DOI: 10.1016/j.ijcard.2015.06.151
  • Peer Reviewed
• [Journal Article] Mechanistic insights of coronary vasospasm and new therapeutic approaches (2015)
  • Author(s): Saitoh S, Takeishi Y, Maruyama Y
  • Journal Title: Fukushima Journal of Medical Science Volume: 61 Pages: 1-12
  • DOI: 10.5387/fms.2015-2
  • Peer Reviewed / Open Access
• [Journal Article] Stenting strategy and follow-up results of multi-center registry in Fukushima city for left main coronary artery disease: bare metal stent versus drug-eluting stent (2015)
  • Author(s): Nakazato K, Mizukami H, Ohtake H, Sakamoto N, Yamaki T, Yamaguchi O, Kunii H, Ohwada T, Takeishi Y
  • Journal Title: Fukushima Journal of Medical Science Volume: 61 Pages: 79-85
  • DOI: 10.5387/fms.2015-5
  • Peer Reviewed / Open Access
• [Journal Article] Association of hypocalcemia with mortality in hospitalized patients with heart failure and chronic kidney disease (2015)
  • Author(s): Miura S, Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Miyata M, Abe S, Sato T, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiac Failure Volume: 21 Pages: 621-627
  • DOI: 10.1016/j.cardfail.2015.04.015
  • Peer Reviewed
• [Journal Article] Relationship of hyperuricemia with mortality in heart failure patients with preserved ejection fraction (2015)
  • Author(s): Shimizu T, Yoshihisa A, Kanno Y, Takiguchi M, Sato A, Miura S, Nakamura Y, Yamauchi H, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: American Journal of Physiology-Heart and Circulatory Physiology Volume: 309 Pages: H1123-H1129
  • DOI: 10.1152/ajpheart.00533.2015
  • Peer Reviewed / Open Access
• [Journal Article] Association of serum n-3/n-6 polyunsaturated fatty acid ratio with T-wave alternans in patients with ischemic heart disease (2015)
  • Author(s): Nodera M, Suzuki H, Yamada S, Kamioka M, Kaneshiro T, Kamiyama Y, Takeishi Y
  • Journal Title: International Heart Journal Volume: 56 Pages: 613-617
  • DOI: 10.1536/ihj.15-185
  • Peer Reviewed / Open Access
• [Journal Article] Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury (2015)
  • Author(s): Shimizu T, Suzuki S, Sato A, Nakamura Y, Ikeda K, Saitoh S, Misaka S, Shishido T, Kubota I, Takeishi Y
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 89 Pages: 306-313
  • DOI: 10.1016/j.yjmcc.2015.10.013
  • Peer Reviewed / Open Access
• [Journal Article] Effect of a low-intensity pulsed ultrasound device, SX-1001, on clinical symptoms in buerger disease with limb ischemia：A Multicenter, Double-Blind, Parallel Randomized Clinical Trial (2015)
  • Author(s): Higashi Y, Azuma N, Takeishi Y, Minamino T, Kihara Y, Node K, Sata M, Fukumoto Y, Origasa H, Matsuo H, Naritomi H, Fujita M, Shimizu W
  • Journal Title: International Heart Journal Volume: 56 Pages: 632-638
  • DOI: 10.1536/ihj.15-191
  • Peer Reviewed / Open Access
• [Journal Article] Membrane type 1-matrix metalloproteinase (MT1-MMP) identified as a multifunctional regulator of vascular responses (2015)
  • Author(s): Ohkawara H, Ikeda K, Ogawa K, Takeishi Y
  • Journal Title: Fukushima Journal of Medical Science Volume: 61 Pages: 91-100
  • DOI: 10.5387/fms.2015-15
  • Peer Reviewed / Open Access
• [Presentation] Appropriate use of biomarkers for heart failure (2016)
  • Author(s): Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
  • Invited
• [Presentation] 大規模災害と心血管病：Decompensated heart failure and atrial fibrillation after the Great East Japan Earthquake (2016)
  • Author(s): Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] 安定型虚血性心疾患の治療戦略構築のための機能的心筋虚血評価：心画像診断のEBMと課題：ACCF/AHA/ASNC appropriateness criteriaにおける画像診断の役割 (2016)
  • Author(s): Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] A comparison study of computed tomography rest myocardial perfusion imaging with fractional flow reserve in coronary artery disease (2016)
  • Author(s): Muto Y, Machii H, Watanabe M, Tatsumi M, Yamaguchi O, Ishibashi T, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Abdominal subcutaneous fat is associated with preclinical right ventricular diastolic dysfunction (2016)
  • Author(s): Oikawa M, Kobayashi A, Satoh T, Suzuki S, Yoshihisa A, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Anatomical relationship among esophagus, left atrium and descending aorta is associated with the transmural thermal injury after pulmonary vein isolation (2016)
  • Author(s): Kaneshiro T, Suzuki H, Nodera M, Kamioka M, Kamiyama Y, Yoshihisa A, Ohkawara H, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Associations of insomnia with prognosis in hospitalized heart failure patients (2016)
  • Author(s): Kanno Y, Yoshihisa A, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Beneficial impact of dipeptidyl-peptidase-4 inhibitors on mortality of hospitalized heart failure patients with diabetes mellitus (2016)
  • Author(s): Sato A, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Determination of left atrial strain is superior beyond CHADS2 and CHA2DS2-VASc scoring for initiating anticoagulation treatment in atrial fibrillation (2016)
  • Author(s): Machii H, Watanabe M, Muto Y, Miyata M, Yamaguchi O, Ishibashi T, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Front line of sleep disordered breathing management: Management of sleep disordered breathing in heart failure patients with preserved left ventricular ejection fraction (2016)
  • Author(s): Yoshihisa A, Suzuki S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Hyperuricemia is a prognostic predictor of all-cause mortality in heart failure with preserved ejection fraction (2016)
  • Author(s): Shimizu T, Yoshihisa A, Takiguchi M, Miura S, Sato A, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Impact of n-3 polyunsaturated fatty acids on mortality of patients with hospitalized heart failure patients (2016)
  • Author(s): Watanabe S, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Intracardiac impedance after cardiac resynchronization therapy is a novel predictor for worsening of heart failure (2016)
  • Author(s): Hitoshi S, Nodera M, Kamioka M, Kaneshiro T, Kamiyama Y, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Prognostic impact and determinants of the oxygen uptake efficiency slope in chronic heart failure (2016)
  • Author(s): Satoh T, Yoshihisa A, Kanno Y, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Prognostic impact of periodic leg movements in hospitalized heart failure patients (2016)
  • Author(s): Kanno Y, Yoshihisa A, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] The association between plasma level of antiangiogenic isoform of vascular endothelial growth factor and clinical profile of peripheral artery disease (2016)
  • Author(s): Sato A, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] The CHA2DS2-VASc score predicts high mortality in hospitalized heart failure patients (2016)
  • Author(s): Watanabe S, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] The impact of anti-angiogenic isoform of vascular endothelial growth factor A in patients with pulmonary hypertension (2016)
  • Author(s): Suzuki S, Nakazato K, Sugimoto K, Yoshihisa A, Yamaki T, Kunii H, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] The occurrence of ventricular tachycardia in cardiomyopathy was associated with circadian variation of abnormal repolarization (2016)
  • Author(s): Nodera M, Suzuki H, Kamioka M, Kaneshiro T, Kamiyama Y, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] The product value of E/E´ and E/A is a novel prognostic index in patients with non-ischemic cardiomyopathy (2016)
  • Author(s): Oikawa M, Kobayashi A, Yoshihisa A, Suzuki S, Satoh T, Sakamoto N, Yamaki T, Kunii H, Nakazato K, Saitoh S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] The prognostic impact of residential environment change after the Great East Japan Earthquake in Fukushima (2016)
  • Author(s): Suzuki S, Yoshihisa A, Watanabe S, Kanno Y, Tsukada S, Kajiwara Y, Watanabe M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Watanabe M, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] 東日本大震災復興5周年 -我々は何を学び、今後、何をなすべきか？-：Clinical features of patients with decompensated heart failure after the Great East Japan Earthquake (2016)
  • Author(s): Yoshihisa A, Yamauchi H, Suzuki S, Takeishi Y
  • Organizer: 第80回 日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury (2015)
  • Author(s): Shimizu T, Suzuki S, Sato A, Nakamura Y, Saitoh S, Shishido T, Kubota I, Takeishi Y
  • Organizer: The 32nd Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Kobe
  • Year and Date: 2015-12-10 – 2015-12-12
• [Presentation] HMGB1 promotes angiogenesis from bone marrow-derived endothelial progenitor cells after myocardial infarction and reduces infarction size (2015)
  • Author(s): Nakamura Y, Suzuki S, Shimizu T, Miyata M, Ikeda K, Saitoh S, Takeishi Y
  • Organizer: The 32nd Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Kobe
  • Year and Date: 2015-12-10 – 2015-12-12
• [Presentation] Phosphodiesterase 3A1 protects the heart against isoproterenol-induced cardiac injury via antioxidative mechanism (2015)
  • Author(s): Oikawa M, Iwaya S, Saitoh S, Takeishi Y
  • Organizer: The 32nd Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Kobe
  • Year and Date: 2015-12-10 – 2015-12-12
• [Presentation] Beneficial impact of dipeptidyl-peptidase-4 inhibitors on mortality of patients with hospitalized heart failure patients with diabetes mellitus (2015)
  • Author(s): Sato A, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury (2015)
  • Author(s): Shimizu T, Suzuki S, Sato A, Nakamura Y, Saitoh S, Mantovani A, Shishido T, Kubota I, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Impact of n-3 polyunsaturated fatty acids on mortality of patients with hospitalized heart failure patients (2015)
  • Author(s): Watanabe S, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Impact of serum uric acid on mortality in heart failure with preserved ejection fraction (2015)
  • Author(s): Shimizu T, Yoshihisa A, Takiguchi M, Miura S, Sato A, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Prognostic impact of periodic leg movements in hospitalized heart failure patients (2015)
  • Author(s): Kanno Y, Yoshihisa A, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Pulmonary artery diameter index predicts the complications of balloon pulmonary angioplasty (2015)
  • Author(s): Sugimoto K, Nakazato K, Yoshihisa A, Sakamoto N, Yamaki T, Kunii H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] The association between plasma levels of anti-angiogenic isoform of vascular endothelial growth factor and clinical profiles of peripheral artery disease (2015)
  • Author(s): Sato A, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] The CHA2DS2-VASc score predicts high mortality in hospitalized heart failure patients (2015)
  • Author(s): Watanabe S, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Sato A, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] The impact of anti-angiogenic isoform of vascular endothelial growth factor a in patients with pulmonary hypertension (2015)
  • Author(s): Suzuki S, Nakakzato K, Sugimoto K, Yoshihisa A, Yamaki T, Kunii H, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] The mitochondria-targeted antioxidant therapy improves age-related cardiovascular dysfunction (2015)
  • Author(s): Owada T, Saitoh S, Yamauchi H, Miura S, Machii H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2015
  • Place of Presentation: Orlando
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Phosphodiesterase 3A1 protects the heart against isoproterenol-induced cardiac injury via anti-oxidative mechanism (2015)
  • Author(s): Oikawa M, Iwaya S, Saitoh S, Yan C, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2015
  • Place of Presentation: London
  • Year and Date: 2015-08-29 – 2015-09-02
  • Int'l Joint Research
• [Presentation] Pseudonormal right ventricular filling pattern reflects left ventricular systolic dysfunction and remodeling (2015)
  • Author(s): Oikawa M, Kobayashi A, Yamauchi H, Suzuki S, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2015
  • Place of Presentation: London
  • Year and Date: 2015-08-29 – 2015-09-02
  • Int'l Joint Research
• [Presentation] A new approach to evaluate the branching angle of the side branch using intravascular ultrasound (2015)
  • Author(s): Sakamoto N, Yamaki T, Kunii H, Nakazato K, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Association of ratio of eicosapentaenoic acid to arachidonic acid with T wave alternans in patients with ischemic heart disease (2015)
  • Author(s): Nodera M, Suzuki H, Kamioka M, Kaneshiro T, Kamiyama Y, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Characteristics of successful ablation with premature ventricular contraction originating from anterior and posterior papillary muscle (2015)
  • Author(s): Kamioka M, Mathew S, Metzner A, Rillig A, Makimoto H, Deiss S, Rausch P, Lemes C, Tina L, Wissner E, Tilz RR, Takeishi Y, Kuck K, Ouyang F
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Decrease of mitochondrial oxidant stress improves age-related cardiac dysfunction (2015)
  • Author(s): Owada T, Yamauchi H, Saitoh S, Machii H, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Deficiency of senescence marker protein-30 impairs collateral growth under ischemia by supressing nitric oxide bioactivity (2015)
  • Author(s): Yamauchi H, Saitoh S, Miura S, Owada T, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] High mobility group box 1 promotes angiogenesis from bone marrow-derived endothelial progenitor cells after myocardial infarction (2015)
  • Author(s): Nakamura Y, Suzuki S, Shimizu T, Saitoh S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Impact of body mass index on mortality in heart failure patients (2015)
  • Author(s): Takiguchi M, Yoshihisa A, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Impact of hypertension on anatomical change of left atrial wall in patients with atrial fibrillation (2015)
  • Author(s): Kamioka M, Suzuki H, Matsumoto Y, Nodera M, Kaneshiro T, Kamiyama Y, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Impact of hypocalcemia on mortality of patients with heart failure and chronic kidney disease (2015)
  • Author(s): Miura S, Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Takiguchi M, Yoshihisa A, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y (2015)
  • Author(s): Impact of insomnia on prognosis in hospitalized heart failure patients
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Impact of peripheral artery disease on prognosis in patients with heart failure (2015)
  • Author(s): Yoshihisa A, Nakamura Y, Kunii H, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Impact of serum uric acid on mortality in heart failure with preserved ejection fraction (2015)
  • Author(s): Shimizu T, Yoshihisa A, Takiguchi M, Miura S, Nakamura Y, Owada T, Yamauchi H, Abe S, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Membrane type1-matrix metalloproteinase (MT1-MMP)/Akt signaling axis modulates TNF-α-induced procoagulant activity and apoptosis in endothelial cells (2015)
  • Author(s): Ohkawara H, Ishibashi T, Sugimoto K, Ogawa K, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Myocardial infarct size quantification in mice using pinhole single-photon emission computed tomography (2015)
  • Author(s): Shimizu T, Nakamura Y, Suzuki S, Kubo H, Ito H, Shishido F, Takenoshita S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Non-invasive positive airway pressure improves mortality in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing (2015)
  • Author(s): Suzuki S, Yoshihisa A, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Non-invasive positive airway pressure ventilation improves cardiac performance (2015)
  • Author(s): Yoshihisa A, Suzuki S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Peripheral artery disease predicts adverse prognosis of heart failure patients (2015)
  • Author(s): Nakamura Y, Yoshihisa A, Kunii H, Shimizu T, Yamauchi H, Abe S, Suzuki S, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Phoshodiesterase 3A1 protects the heart against isoproterenol–induced cardiac injury via anti-oxidative mechanism (2015)
  • Author(s): Oikawa M, Iwaya S, Saitoh S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Prevalence of atrial fibrillation increased among residents in the evacuation zone of Fukushima prefecture after the Great East Japan Earthquake (2015)
  • Author(s): Hitoshi S, Ohira T, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] The abdominal visceral adipose tissue is associated with cardiac valve calcification (2015)
  • Author(s): Oikawa M, Owada T, Yamauchi H, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] The impact of plasma levels of receptor for advanced glycation end-products and high mobility group box 1 in pulmonary hypertension (2015)
  • Author(s): Suzuki S, Nakazato K, Sugimoto K, Yoshihisa A, Yamaki T, Kunii H, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] The usefulness of transtricuspid flow pattern to stratify the patients with impaired left ventricular diastolic function (2015)
  • Author(s): Oikawa M, Kobayashi A, Yamauchi H, Suzuki S, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26