糖尿病を合併した虚血性心不全に対する治療戦略

2016 Fiscal Year Research-status Report

• Project/Area Number: 15K09143
• Research Institution: Fukushima Medical University
• Principal Investigator: 竹石 恭知 福島県立医科大学, 医学部, 教授 (40272067)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: myocardial infarction / heart failure / diabetes mellitus / HMGB1 / DPP4

Outline of Annual Research Achievements

心筋にのみ選択的に HMGB1 遺伝子を高発現したトランスジェニックマウス (HMGB1-TG)と野生型マウスにストレプトゾトシンを腹腔内投与し糖尿病状態とし、冠動脈左前下行枝を結紮し、心筋梗塞を作成した。
糖尿病状態では、非糖尿病状態と異なり、GFP 陽性の骨髄由来 EPC 数、心重量、肺重量、心筋梗塞サイズ、梗塞周囲部の capillary density と GFP 陽性の骨髄由来血管内皮細胞数に差異を認めなかった。糖尿病マウスでは DPP4 活性が上昇しており、心筋梗塞後の HMGB1 濃度の上昇は見られなかった。
そこで、糖尿病マウスに DPP4 阻害薬を投与した。ストレプトゾトシン投与は１型糖尿病モデルのため、DPP4 阻害薬投与では血糖の低下は認められなかったが、DPP4 活性は十分に抑制されたことを確認した。冠動脈左前下行枝を結紮し、同様に心筋梗塞を作成したところ、心筋梗塞後の HMGB1 濃度の上昇が認められた。DPP4 阻害薬を投与した糖尿病 HMGB1-TG マウスでは、DPP4 阻害薬を投与しない糖尿病 HMGB1-TG マウスに比較し、心筋梗塞サイズの縮小効果が認められた。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

糖尿病で DPP4 活性が上昇し、血中の HMGB1 濃度は低下したが、DPP4 阻害薬を投与することで血中の HMGB1 濃度が上昇したのを確認できた。また、DPP4 阻害薬投与により、糖尿病 HMGB1-TG マウスで心筋梗塞サイズの縮小効果が認められた。

Strategy for Future Research Activity

DPP4 阻害薬による心筋梗塞サイズ抑制効果に関して、詳細なメカニズムを解明していく。

Research Products

• [Journal Article] Vulnerable plaque on the common iliac artery detected by 18F-fluorodeoxyglucose PET/MRI (2016)
  • Author(s): Atsuro Masuda, Takayoshi Yamaki, Nobuo Sakamoto, Hiroyuki Kunii, Hiroshi Ito, Takeyuki Nanbu, Hitoshi Kubo, Takamitsu Hara, Seiichi Takenoshita, Yasuchika Takeishi
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 43 Pages: 793-794
  • DOI: 10.1007/s00259-015-3296-y
  • Peer Reviewed / Open Access
• [Journal Article] The CHA2DS2-VASc score as a predictor of high mortality in hospitalized heart failure patients (2016)
  • Author(s): Akiomi Yoshihisa, Shunsuke Watanabe, Yuki Kanno, Mai Takiguchi, Akihiko Sato, Tetsuro Yokokawa, Shunsuke Miura, Takeshi Shimizu, Satoshi Abe, Yasuchika Takeshi, et al
  • Journal Title: ESC Heart Failure Volume: 3 Pages: 261-269
  • DOI: 10.1002/ehf2.12098
  • Peer Reviewed / Open Access
• [Journal Article] The association between circulating anti-angiogenic isoform of vascular endothelial growth factor and clinical profiles in patients with peripheral artery disease (2016)
  • Author(s): Akihiko Sato, Akiomi Yoshihisa, Tetsuro Yokokawa, Takeshi Shimizu, Yuichi Nakamura, Tomofumi Misaka, Masashi Kamioka, Takashi Kaneshiro, Satoshi Suzuki, Hiroyuki Kunii, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: International Journal of Cardiology Volume: 207 Pages: 368-369
  • DOI: 10.1016/j.ijcard.2016.01.189
  • Peer Reviewed
• [Journal Article] Simultaneous cardiac imaging to detect inflammation and scar tissue with 18F-fluorodeoxyglucose PET/MRI in cardiac sarcoidosis (2016)
  • Author(s): Kento Wada, Takeo Niitsuma, Takayoshi Yamaki, Atsuro Masuda, Hiroshi Ito, Hitoshi Kubo, Takamitsu Hara, Seiichi Takenoshita, Yasuchika Takeishi
  • Journal Title: Journal of Nuclear Cardiology Volume: 23 Pages: 1180-1182
  • DOI: 10.1007/s12350-015-0348-4
  • Peer Reviewed
• [Journal Article] Senescence marker protein-30 deficiency impairs angiogenesis under ischemia (2016)
  • Author(s): Hiroyuki Yamauchi, Shunsuke Miura, Takashi Owada, Shu-ichi Saitoh, Hirofumi Machii, Shinya Yamada, Akihito Ishigami, Yasuchika Takeishi
  • Journal Title: Free Radical Biology and Medicine Volume: 94 Pages: 66-73
  • DOI: 10.1016/j.freeradbiomed.2016.02.020
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary arterial capacitance predicts cardiac events in pulmonary hypertension due to left heart disease (2016)
  • Author(s): Koichi Sugimoto, Akiomi Yoshihisa, Kazuhiko Nakazato, Yuichiro Jin, Satoshi Suzuki, Tetsuro Yokokawa, Tomofumi Misaka, Takayoshi Yamaki, Hiroyuki Kunii, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: PLOS ONE Volume: 11 Pages: e0165603
  • DOI: 10.1371/journal.pone.0165603
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of insomnia in heart failure (2016)
  • Author(s): Yuki Kanno, Akiomi Yoshihisa, Shunsuke Watanabe, Mai Takiguchi, Tetsuro Yokokawa, Akihiko Sato, Shunsuke Miura, Takeshi Shimizu, Yuichi Nakamura, Satoshi Abe, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: Circulation Journal Volume: 80 Pages: 1571-1577
  • DOI: 10.1253/circj.CJ-16-0205
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of periodic leg movements during sleep in heart failure patients (2016)
  • Author(s): Akiomi Yoshihisa, Satoshi Suzuki, Yuki Kanno, Mai Takiguchi, Akihiko Sato, Shunsuke Miura, Atsuro Masuda, Tetsuro Yokokawa, Takeshi Shimizu, Yuichi Nakamura, Hiroyuki Yamauchi, Takashi Owada, Satoshi Abe, Takamasa Sato, Masayoshi Oikawa, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: International Journal of Cardiology Volume: 212 Pages: 11-13
  • DOI: 10.1016/j.ijcard.2016.03.007
  • Peer Reviewed
• [Journal Article] Predominance of abdominal visceral adipose tissue reflects the presence of aortic valve calcification (2016)
  • Author(s): Masayoshi Oikawa, Takashi Owada, Hiroyuki Yamauchi, Tomofumi Misaka, Hirofumi Machii, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: BioMed Research International Volume: 2016 Pages: 2174657
  • DOI: 10.1155/2016/2174657
  • Peer Reviewed / Open Access
• [Journal Article] Plasma leves of receptor for advanced glycation end-products and high-mobility group box 1 in patients with pulmonary hypertension (2016)
  • Author(s): Satoshi Suzuki, Kazuhiko Nakazato, Koichi Sugimoto, Akiomi Yoshihisa, Takayoshi Yamaki, Hiroyuki Kunii, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: International Heart Journal Volume: 57 Pages: 230-240
  • DOI: 10.1536/ihj.15-188
  • Peer Reviewed / Open Access
• [Journal Article] Midkine deteriorates cardiac remodeling via epidermal growth factor receptor signaling in chronic kidney disease (2016)
  • Author(s): Yuki Honda, Tetsuro Shishido, Tetsuya Takahashi, Tetsu Watanabe, Shunsuke Netsu, Daisuke Kinoshita, Taro Narumi, Shinpei Kadowaki, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takuya Miyamoto, Satoshi Kishida, Kenji Kadomatsu, Yasuchika Takeishi, Isao Kubota
  • Journal Title: Hypertension Volume: 67 Pages: 857-865
  • DOI: 10.1161/HYPERTENSIONAHA.115.06922
  • Peer Reviewed / Open Access
• [Journal Article] Mapping strategy associated with QRS morphology for catheter ablation in patients with idiopathic ventricular outflow tract tachyarrhythmia (2016)
  • Author(s): Takashi Kaneshiro, Hitoshi Suzuki, Minoru Nodera, Shinya Yamada, Masashi Kamioka, Yoshiyuki Kamiyama, Yasuchika Takeishi
  • Journal Title: Pacing and Clinical Electrophysiology Volume: 39 Pages: 338-344
  • DOI: 10.1111/pace.12810
  • Peer Reviewed / Open Access
• [Journal Article] Intravascular ultrasound predictors of acute side branch occlusion in coronary artery bifurcation lesions just after single stent crossover (2016)
  • Author(s): Nobuo Sakamoto, Yasuto Hoshino, Hiroyuki Mizukami, Koichi Sugimoto, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: Catheterization and Cardiovascular Interventions Volume: 87 Pages: 243-250
  • DOI: 10.1002/ccd.26021
  • Peer Reviewed / Open Access
• [Journal Article] Fibrillatory excitation in the pulmonary vein is associated with the presence of dissociated pulmonary vein activity after isolation (2016)
  • Author(s): Takashi Kaneshiro, Hitoshi Suzuki, Minoru Nodera, Masashi Kamioka, Yoshiyuki Kamiyama, Yasuchika Takeishi
  • Journal Title: Journal of Interventional Cardiac Electrophysiology Volume: 47 Pages: 231-236
  • DOI: 10.1007/s10840-016-0154-1
  • Peer Reviewed
• [Journal Article] Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and zebra body (2016)
  • Author(s): Masayoshi Oikawa, Nobuo Sakamoto, Atsushi Kobayashi, Satoshi Suzuki, Akiomi Yoshihisa, Takayoshi Yamaki, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yuichirou Kiko, Hajime Nakano, Takeharu Hayashi, Akinori Kimura, Yasuchika Takeishi
  • Journal Title: BMC Cardiovascular Disorders Volume: 16 Pages: 83
  • DOI: 10.1186/s12872-016-0262-y
  • Peer Reviewed / Open Access
• [Journal Article] Deficiency of senescence marker protein 30 exacerbates cardiac injury after ischemia/reperfusion (2016)
  • Author(s): Shinpei Kadowaki, Tetsuro Shishido, Toshiki Sasaki, Takayuki Sugai, Taro Narumi, Yuki Honda, Yoichiro Otaki, Daisuke Kinoshita, Tetsuya Takahashi, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takuya Miyamoto, Tetsu Watanabe, Akihiko Ishigami, Yasuchika Takeishi, Isao Kubota
  • Journal Title: International Journal of Molecular Sciences Volume: 17 Pages: 542
  • DOI: 10.3390/ijms17040542
  • Peer Reviewed / Open Access
• [Journal Article] Associations with eicosapentaenoic acid to arachidonic acid ratio and mortality in hospitalized heart failure patients (2016)
  • Author(s): Shunsuke Watanabe, Akiomi Yoshihisa, Yuki Kanno, Mai Takiguchi, Tetsuro Yokokawa, Akihiko Sato, Shunsuke Miura, Takeshi Shimizu, Satoshi Abe, Yasuchika Takeshi, et al
  • Journal Title: Journal of Cardiac Failure Volume: 22 Pages: 962-969
  • DOI: 10.1016/j.cardfail.2016.04.017
  • Peer Reviewed / Open Access
• [Journal Article] Associations of dipeptidyl peptidase-4 inhibitors with mortality in hospitalized heart failure patients with diabetes mellitus (2016)
  • Author(s): Akihiko Sato, Akiomi Yoshihisa, Yuki Kanno, Mai Takiguchi, Shunsuke Miura, Takeshi Shimizu, Yuichi Nakamura, Hiroyuki Yamauchi, Takashi Owada, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: ESC Heart Failure Volume: 3 Pages: 77-85
  • DOI: 10.1002/ehf2.12079
  • Peer Reviewed / Open Access
• [Journal Article] Association between levels of anti-angiogenic isoform of vascular endothelial growth factor A and pulmonary hypertension (2016)
  • Author(s): Satoshi Suzuki, Akiomi Yoshihisa, Tetsuro Yokokawa, Tomofumi Misaka, Nobuo Sakamoto, Koichi Sugimoto, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: International Journal of Cardiology Volume: 222 Pages: 416-420
  • DOI: 10.1016/j.ijcard.2016.07.277
  • Peer Reviewed
• [Journal Article] Choosing the appropriate examination for diagnosis of stable ischemic heart disease (2016)
  • Author(s): Atsuro Masuda, Yasuchika Takeishi
  • Journal Title: Annals of Nuclear Cardiology Volume: 2 Pages: 167-173
  • DOI: 10.17996/ANC.02.01.167
  • Peer Reviewed / Open Access
• [Presentation] 慢性心不全における多面的アプローチ (2017)
  • Author(s): 竹石恭知
  • Organizer: 第2回 KCHARTセミナー
  • Place of Presentation: 倉敷
  • Year and Date: 2017-03-10
  • Invited
• [Presentation] Resolution of mitochondrial oxidative stress improves age-related collateral development with ischemia through p53 and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) (2016)
  • Author(s): Shunsuke Miura, Tomoki Kokubun, Shu-ichi Saitoh, Takafumi Ishida, Yasuchika Takeishi
  • Organizer: Cardiovascular and Metabolic Week 2016: The 33rd Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Tokyo
  • Year and Date: 2016-12-16 – 2016-12-17
  • Int'l Joint Research
• [Presentation] The DPP4 inhibition ameliorates cardiac function by inhibiting the cleavage of HMGB-1 in diabetic mice after myocardial infarction (2016)
  • Author(s): Akihiko Sato, Satoshi Suzuki, Shunsuke Watanabe, Takeshi Shimizu, Yuichi Nakamura, Shu-ichi Saitoh, Takafumi Ishida, Yasuchika Takeishi
  • Organizer: Cardiovascular and Metabolic Week 2016: The 33rd Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Tokyo
  • Year and Date: 2016-12-16 – 2016-12-17
  • Int'l Joint Research
• [Presentation] Association between sleep disordered breathing and arterial stiffness in heart failure patients with reduced or preserved ejection fraction (2016)
  • Author(s): Satoshi Suzuki, Akiomi Yoshihisa, Yu Sato, Tetsuro Yokokawa, Shunsuke Miura, Takamasa Sato, Shunsuke Watanabe, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Comparisons of cardiopulmonary exercise testing between heart failure with reduced ejection fraction and preserved ejection fraction (2016)
  • Author(s): Takamasa Sato, Yuki Kanno, Akiomi Yoshihisa, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Influence of the Great Easte Japan Earthquake and subsequent nuclear power plant accident on the incidence and mortality of acute myocardial infarction in Fukushima (2016)
  • Author(s): Kazuhiko Nakazato, Takayoshi Yamaki, Satoshi Suzuki, Akiomi Yoshihisa, Hiroyuki Kunii, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Anatomical situation surrounding the esophagus affects the prevalence of transmural thermal injury after pulmonary vein isolation (2016)
  • Author(s): Takashi Kaneshiro, Hitoshi Suzuki, Yoshiyuki Matsumoto, Minoru Nodera, Masashi Kamioka, Yoshiyuki Kamiyama, Akiomi Yoshihisa, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Simultaneous assessment of myocardial viability with 18F-fluorodeoxyglucose uptake and late gadolinium enhancement by PET/MRI (2016)
  • Author(s): Atsuro Masuda, Takayoshi Yamaki, Hiroyuki Kunii, Takeyuki Nanbu, Takamitsu Hara, Hitoshi Kubo, Hiroshi Ito, Seiichi Takenoshita, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Midkine contributes the development of pulmonary arterial hypertension via cell surface nucleolin (2016)
  • Author(s): Daisuke Kinoshita, Tetsuro Shishido, Tetsuya Takahashi, Miyuki Yokoyama, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takuya Miyamoto, Tetsu Watanabe, Tsuneo Konta, Kenji Kadomatsu, Yasuchika Takeishi, Isao Kubota
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Liver fibrosis score predicts mortality in heart failure patients with preserved ejection fraction (2016)
  • Author(s): Yu Sato, Akiomi Yoshihisa, Shunsuke Watanabe, Tetsuro Yokokawa, Shunsuke Miura, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Associations between acylcarnitine to total carnitine ratio and adverse prognosis in heart failure patients with reduced or preserved ejection fraction (2016)
  • Author(s): Shunsuke Watanabe, Akiomi Yoshihisa, Yu Sato, Tetsuro Yokokawa, Shunsuke Miura, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Uncontrolled blood pressure is a predictor of left atrial remodeling and adverse clinical outcome after pulmonary vein isolation in patients with paroxysmal atrial fibrillation (2016)
  • Author(s): Masashi Kamioka, Hitoshi Suzuki, Yoshiyuki Matsumoto, Minoru Nodera, Takashi Kaneshiro, Yoshiyuki Kamiyama, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Liver stiffness assessed by Fib4 index predicts mortality in heart failure patients (2016)
  • Author(s): Yu Sato, Akiomi Yoshihisa, Shunsuke Watanabe, Tetsuro Yokokawa, Shunsuke Miura, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Plasma volume status predicts mortality in heart failure patients (2016)
  • Author(s): Yu Sato, Akiomi Yoshihisa, Shunsuke Watanabe, Tetsuro Yokokawa, Shunsuke Miura, Takamasa Sato, Satoshi Abe, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] The product of E/A and log BNP is a novel parameter to predict left ventricular filling pressure (2016)
  • Author(s): Masayoshi Oikawa, Atsushi Kobayashi, Kento Wada, Takamasa Sato, Satoshi Suzuki, Akiomi Yoshihisa, Kazuhiko Nakazato, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Associations between proton pump inhibitors and low cardiac mortality in patients with heart failure (2016)
  • Author(s): Mai Takiguchi, Akiomi Yoshihisa, Yu Sato, Shunsuke Watanabe, Tetsuro Yokokawa, Shunsuke Miura, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Uric acid is a useful marker to predict the occurrence of ventricular tachyarrythmias in cardiomyopathy patients with primary prevention icd implantation (2016)
  • Author(s): Minoru Nodera, Hitoshi Suzuki, Masashi Kamioka, Takashi Kaneshiro, Yoshiyuki Kamiyama, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Pericellular amyloid infiltration in biopsy-proven cardiac amyloidosis (2016)
  • Author(s): Tetsuro Yokokawa, Yasuo Sugano, Taka-aki Matsuyama, Kanzaki Hideaki, Keiko Ohta-Ogo, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Yasuchika Takeishi, Satoshi Yasuda, Toshihisa Anzai
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Mitochondria-targeted antioxidant therapy improves age-related collateral development with ischemia through p53 and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) (2016)
  • Author(s): Shunsuke Miura, Tomoki Kokubun, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Pulmonary hypertension with thickening of adventitial area due to decreased eNOS bioavailability in senescence marker protein-30 knock-out mice (2016)
  • Author(s): Koichi Sugimoto, Akihiko Sato, Shunsuke Watanabe, Satoshi Suzuki, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Importance of pulmonary arterial capacitance in pulmonary hypertension with left heart disease (2016)
  • Author(s): Koichi Sugimoto, Kazuhiko Nakazato, Akiomi Yoshihisa, Takamasa Sato, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Koichi Sugimoto, Akihiko Sato, Shunsuke Watanabe, Satoshi Suzuki, Takeshi Machida, Shu-ichi Saitoh, Hideharu Sekine, Yasuchika Takeishi (2016)
  • Author(s): Pulmonary hypertension with altered eNOS and ALK-1 signaling in the autoimmuno-disease mice
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Decrease of senescence marker protein-30 in aging impairs collateral growth under ischemia (2016)
  • Author(s): Shu-ichi Saitoh, Hiroyuki Yamauchi, Takashi Owada, Shunsuke Miura, Tomoki Kokubun, Yasuchika Takeishi
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Usefulness of pulmonary artery diameter measurements to predict lung infiltration after balloon pulmonary angioplasty (2016)
  • Author(s): Koichi Sugimoto, Kazuhiko Nakazato, Nobuo Sakamoto, Takayoshi Yamaki, Hiroyuki Kunii, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: Congress of the European Society of Cardiology 2016
  • Place of Presentation: Rome
  • Year and Date: 2016-08-27 – 2016-08-31
  • Int'l Joint Research
• [Presentation] Apolipoprotein b level correlates with the necrotic core in a lesion plaque in patients with stable coronary disease (2016)
  • Author(s): Takayuki Ohwada, Kenichi Watanabe, Takayuki Sakamoto, Yasuchika Takeishi
  • Organizer: Congress of the European Society of Cardiology 2016
  • Place of Presentation: Rome
  • Year and Date: 2016-08-27 – 2016-08-31
  • Int'l Joint Research
• [Presentation] Joint session with the Heart Failure Society of America and The Japanese Heart Failure Society: A global view on the new heart failure guideline: crossing the great divide (symposium) (2016)
  • Author(s): Yasuchika Takeishi
  • Organizer: Heart Failure Congress 2016 and 3rd World Congress on Acute Heart Failure
  • Place of Presentation: Florence
  • Year and Date: 2016-05-21 – 2016-05-24
  • Int'l Joint Research
• [Presentation] Phosphodiesterase 3A1 prevents cardiac remodeling from neurohormonal activation (2016)
  • Author(s): Masayoshi Oikawa, Shoji Iwaya, Shu-ichi Saitoh, Yasuchika Takeishi
  • Organizer: 22nd World Congress of the International Society for Heart Research (ISHR)
  • Place of Presentation: Buenos Aires
  • Year and Date: 2016-04-18 – 2016-04-21
  • Int'l Joint Research