The role of integrin in the development of abdominal aortic aneurysm

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09157
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Okayama University
• Principal Investigator: MIYOSHI Toru 岡山大学, 大学病院, 講師 (70444651)
• Co-Investigator(Kenkyū-buntansha): 中村 一文 岡山大学, 医歯薬学総合研究科, 准教授 (10335630) ; 米澤 朋子 岡山大学, 医歯薬学総合研究科, 助教 (30304299) ; 吉田 賢司 岡山大学, 医歯薬学総合研究科, 講師 (70532761) ; 伊藤 浩 岡山大学, 医歯薬学総合研究科, 教授 (90446047)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 腹部大動脈瘤 / 接着因子 / インテグリン

Outline of Final Research Achievements

Abdominal aortic aneurysm is a silent disease, but lethal once ruptured. The prevention of AAA expansion and rupture is clinically difficult. This study investigated whether alpha1 integrin, an adhesion molecule, is involved in the development of AAA in murine model. Genetic deficiency of alpha1 integrin suppressed the rupture of AAA in angiotensin II infusion model. These findings suggest that alpha1 integrin may be a promising target to treat AAA.

Free Research Field

動脈硬化性疾患の発症・進展における細胞外マトリックス関連分子の役割の解明