Analysis for alteration of fatty acid fraction in COPD and idiopathic pulmonary fibrosis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09167
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Gunma University
• Principal Investigator: MAENO TOSHITAKA 群馬大学, 医学部附属病院, 講師 (00436297)
• Co-Investigator(Kenkyū-buntansha): 倉林 正彦 群馬大学, 大学院医学系研究科, 教授 (00215047) ; 松井 弘樹 群馬大学, 大学院保健学研究科, 講師 (20431710) ; 横山 知行 群馬大学, 大学院保健学研究科, 教授 (70312890)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: COPD / 特発性肺線維症 / 脂肪酸 / 脂肪酸分画

Outline of Final Research Achievements

COPD (chronic obstructive pulmonary disease) and idiopathic pulmonary fibrosis have not been established the treatment that leads to the improvement of the fundamental pathological condition, and the elucidation of the pathology and development of the treatment are truly needed. We clarified that pulmonary emphysema is caused by alteration of fatty acid fraction and further pulmonary fibrosis deteriorates. Based on that, we investigated in this study whether the fatty acid composition balance has changed in COPD or idiopathic pulmonary fibrosis patients. As a result, the tendency of the change in fatty acid composition balance, Elovl 6 activity and SCD 1 activity were recognized in COPD and idiopathic pulmonary fibrosis, but at the present time we could not reach a conclusion about the pathological significance.

Free Research Field

COPD　間質性肺炎