Why is there an area priority during development of emphysema and fibrosis in the human lung? Approach to elucidate the mechanisms by mechanical property of the lung

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09186
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nara Medical University
• Principal Investigator: TOMODA KOICHI 奈良県立医科大学, 医学部, 病院教授 (90364059)
• Co-Investigator(Kenkyū-buntansha): 吉川 雅則 奈良県立医科大学, 医学部, 病院教授 (80271203) ; 木村 弘 日本医科大学, 大学院医学研究科, 教授 (20195374) ; 大崎 茂芳 奈良県立医科大学, 医学部, 研究員 (90273911)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: コラーゲン線維 / 配向性 / 気腫化 / 繊維化 / 不均等分布 / 力学特性 / 異方性

Outline of Final Research Achievements

We tried to elucidate the mechanisms there exists an area priority during development of emphysema and fibrosis in the human lung from a view point of mechanical property. On the lung without any lung diseases the collagen fiber was orientated mainly in up and down direction. The breaking stress was relatively higher in up and down direction than that in inner and outer direction. The mechanical anisotropy on the human lung was correlated with the anisotropy of the collagen fiber orientation. The distribution of the collagen fiber orientation on the lung with both emphysema and fibrosis is different from that without any lung diseases. Especially on the lung with emphysema there existed an area where the collagen fiber was highly orientated. These results may suggest that the mechanical stresses by respiration may contribute to the reconstruction in collagen fiber orientation during the development of emphysema.

Free Research Field

呼吸器内科学