The analyses of cell type-specific extracellular vesicles derived from lung quiescent or cytokine-activated lung endothelial cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09206
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: YAMADA MITSUHIRO 東北大学, 大学病院, 助教 (00396483)
• Co-Investigator(Kenkyū-buntansha): 吉岡 祐亮 (吉岡祐亮) 国立研究開発法人国立がん研究センター, 研究所, 研究員 (60721503)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: バイオマーカー / COPD / IPF / エクソソーム / 細胞外小胞

Outline of Final Research Achievements

Serum EV miR-21-5p was elevated in both the acute inflammatory phase (day 7) and the chronic fibrotic phase (day 28) in the mouse model. In the clinical setting, serum EV miR-21-5p was significantly higher in IPF patients than in healthy control subjects. The baseline serum EV miR-21-5p was correlated with the rate of decline in vital capacity over 6 months. Furthermore, serum EV miR-21-5p was independently associated with mortality during the following 30 months, even after adjustment for other variables. In the survival analysis, IPF patients whose baseline serum EV miR-21-5p was high had a significantly poorer prognosis over 30 months. Our results suggest that serum EV miR-21-5p has potential as a prognostic biomarker for IPF.

Free Research Field

呼吸器内科学分野