Elucidation of various pathophysiology of refractory pulmonary arterial lesions in PAH rat model with lung transplantation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09210
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Chiba University
• Principal Investigator: Sakao Seiichiro 千葉大学, 医学部附属病院, 講師 (80431740)
• Co-Investigator(Kenkyū-buntansha): 巽 浩一郎 千葉大学, 大学院医学研究院, 教授 (10207061) ; 江本 憲昭 神戸薬科大学, 薬学部, 教授 (30294218) ; 岩田 剛和 千葉県がんセンター(研究所), 呼吸器外科, 部長 (30586681) ; 田邉 信宏 千葉大学, 大学院医学研究院, 特任教授 (40292700) ; 鈴木 秀海 千葉大学, 大学院医学研究院, 講師 (60422226)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺動脈性肺高血圧症 / 肺移植

Outline of Final Research Achievements

Refractory pulmonary arterial lesions against vasodilator drugs were confirmed in PAH rat model ( i.e., Su/Hx model). After a successful single lung transplant in normal rats, we tried a single lung transplant in Su/Hx model. However, almost transplants failed due to high pulmonary arterial pressure and right heart overload. In a very few successful cases, pulmonary lesions ameliorated. Subsequently, there was no successful lung transplant n Su/Hx model. Now, together with it, a single lung transplant between male and female rats was tried to elucidate pathophysiology of vascular lesions. Data about bone marrow derived cells in medial and intimal lesions are accumulated by using FISH analysis.

Free Research Field

呼吸器内科