Analysis of mechanical stress in lung cancer cells for therapeutic target search

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09216
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Fujita Health University (2017); Nagoya University (2015-2016)
• Principal Investigator: Kondo Masashi 藤田保健衛生大学, 医学部, 教授 (00378077)
• Co-Investigator(Kenkyū-buntansha): 伊藤 理 愛知医科大学, 医学部, 准教授 (60378073) ; 佐藤 光夫 名古屋大学, 医学部附属病院, 准教授 (70467281)
• Research Collaborator: Miyazawa Ayako
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺癌

Outline of Final Research Achievements

Cancer cells have a specific response to the physical force from the surroundings. Physical stimuli such as stretch stimulation and changes in matrix stiffness were applied to lung cancer cell lines and its effect on cell proliferation and molecular expression was examined. As the matrix stiffness decreased, expression of PD-L1 decreased and cell proliferation was suppressed. From pharmacological experiments, it was due to an actin-dependent mechanism. it was suggested that the physical microenvironment of the tumor such as matrix stiffness, is also involved in the regulation of tumor immunity.

Free Research Field

呼吸器