2017 Fiscal Year Final Research Report
Innovation of drug seeds against B7-H1 involved in exacerbation of obstructive lung diseases
| Project/Area Number |
15K09222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
福山 聡 九州大学, 大学病院, 講師 (50380530)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | B7-H1 / PD-L1 / 気管支喘息 / COPD / ウィルス感染 / 複合病態 |
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| Outline of Final Research Achievements |
Airway viral infections cause the exacerbations of obstructive lung diseases. B7-H1/PD-L1 is an immune-checkpoint molecule that plays a role in an escape mechanism of viruses from the host immune systems. This escape may be associated with the persistence of viral infection and the exacerbation of the underlying diseases. In a study in vitro, we have shown that a PI3-kinase-delta inhibitor attenuated the upregulation of B7-H1/PD-L1 on airway epithelial cells stimulated with an analog of viral double-stranded(ds) RNA. In this study, we investigated the effect of PI3-kinase inhibitor on the expression of B7-H1/PD-L1 in dsRNA-induced inflammation in mice. Administration of dsRNA upregulated the expression of B7-H1/PD-L1 and induced neutrophilic inflammation, which were suppressed by pretreatment with the PI3-kinase inhibitor. These results suggest PI3-kinase-delta inhibitor as a candidate of clinical use for preventing the virus-induced exacerbations of obstructive lung diseases.
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| Free Research Field |
呼吸器病学
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