Mechanism of microRNA expression regulation and utility of microRNA as a biomarker in renal disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09240
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Yamagata University
• Principal Investigator: Konta Tsuneo 山形大学, 医学部, 教授 (60333952)
• Co-Investigator(Renkei-kenkyūsha): KAMEI Keita 山形大学, 内科学第一講座 (60756526)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: microRNA / urine

Outline of Final Research Achievements

In a cohort study, it was revealed that renal dysfunction, hyperuricemia and leakage of albumin in urine are independent risk factors for all-cause and cardiovascular mortalities in the participants of general health check in Japan. In a study of patients with renal diseases, a variety of microRNAs are expressed in the glomerular, renal tubular, and interstitial cells, and their expression profiles vary depending on the types of renal diseases. In longitudinal study of IgA nephropathy, the expression levels of specific types of microRNAs in urine sample correlate with the one-year decline of renal function. Based on these findings, it was shown that renal disorder and urine biomarkers are useful as indicators of all-cause and cardiovascular mortalities in general population, and renal prognosis in the patients with renal diseases.

Free Research Field

腎臓内科学