Analysis of the Role of Renal Dendritic Cells in the Progression of Renal Injury

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09243
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Gunma University
• Principal Investigator: Hiromura Keiju 群馬大学, 大学院医学系研究科, 准教授 (70292597)
• Co-Investigator(Renkei-kenkyūsha): KANEKO Yoriaki 群馬大学, 医学部附属病院, 講師 (00334095)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 腎臓病 / 尿細管間質性腎炎 / 樹状細胞 / 腎不全 / 腎単核食細胞

Outline of Final Research Achievements

CD11c-specific Shp-1 deficient mice (Shp1-CKO mice) spontaneously develop tubulointerstitial nephritis together with proliferative glomerulonephritis. In this study, we further examined the details of intrarenal immune-inflammatory cells in the kidney using flow cytometric analysis. CD11c (dendritic cell marker) and F4/80 (macrophage marker) double-positive renal mononuclear phagocytes were activated and increased in the kidney of Shp1-CKO mice. These renal mononuclear phagocytes are considered to induce accumulation of Th1 cells and possibly directly be involved in renal fibrosis. Our study showed that the mechanisms of tubulointerstitial injury and fibrosis via renal mononuclear phagocytes. In addition, Shp1 would play an important role in regulation of renal mononuclear phagocytes.

Free Research Field

腎臓病学