2017 Fiscal Year Final Research Report
Development of novel kidney regeneration therapy using iPS cell-derived kidney tissue stem cells
| Project/Area Number |
15K09244
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University (2016-2017)
The University of Tokyo (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
菱川 慶一 慶應義塾大学, 医学部(信濃町), 特任准教授 (50255460)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | iPS細胞 |
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| Outline of Final Research Achievements |
By using MyoR positivity as an index from iPS cells, kidney tissue stem cells were induced to differentiate, and kidney regenerating action in CKD model of kidney tissue stem cell transplantation was examined. Specifically, MyoR positive cells FACS isolated from kidney tissue, and MyoR positive cells differentiated from iPS cells were transplanted into three kinds of chronic renal failure models, and the renewal function and regeneration action against tissue damage were compared. Although the problem of reproducibility remains, MyoR positive cells are suggested to have a recovery action of kidney function, which is considered to be a fundamental data aiming at development of a novel CKD therapy method using human iPS cells.
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| Free Research Field |
再生医療
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