Protein-bound uremic toxins-induced functional abnormalities of HDL cholesterol for prevention of atherosclerosis accelerated by chronic kidney disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09249
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Niigata University
• Principal Investigator: Yamamoto Suguru 新潟大学, 医歯学総合病院, 准教授 (70444156)
• Co-Investigator(Renkei-kenkyūsha): KAZAMA Junichiro 福島県立医科大学, 医学部, 教授 (10345499) ; NARITA Ichiei 新潟大学, 医歯学系, 教授 (20272817) ; MARUYAMA Toru 熊本大学, 薬学部, 教授 (90423657) ; KOTANI Kazuhiko 自治医科大学, 医学部, 教授 (60335510)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: インドキシル硫酸 / マクロファージ / HDL / 吸着 / インフラマソーム / MAPK / NF-ｋB

Outline of Final Research Achievements

Chronic　kidney　disease (CKD),　especially　those　undergoing　dialysis　treatment,　have　high　risk　of　cardiovascular disease.　We focused on function of high- density lipoprotein (HDL）and protein-bound　uremic　toxins　(PBUTs),　and　found　the　role　of　PBUTs　on　functional　abnormalities　of　HDL　to　macrophage. Further, we investigated the adsorption treatment for PBUTs with direct hemoperfusion. Thus, we have found the role of PBUTs for HDL and macrophage function and suggested a novel therapeutic strategies for removal of PBUTs for the prevention of cardiovascular disease in CKD patients.

Free Research Field

腎臓内科