The role of fructose metabolism in the development of chronic kidney disease and hypertension.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09255
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: ISHIMOTO TAKUJI 名古屋大学, 医学部附属病院, 助教 (00534835)
• Co-Investigator(Kenkyū-buntansha): 丸山 彰一 名古屋大学, 医学系研究科, 教授 (10362253) ; 小杉 智規 名古屋大学, 医学部附属病院, 講師 (90584681)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 塩分感受性高血圧 / フルクトース / ケトヘキソキナーゼ

Outline of Final Research Achievements

The aim of this study is to elucidate the role of fructose metabolism by the primary enzyme of fructose, ketohexokinase (KHK) in hypertension. In this study, by using KHK knockout mice (KHK-KO), we found that the combination of fructose and high salt induced the elevation of blood pressure with decrease of sodium excretion and increase of mRNA expression of NHE3 in kidney in wild type mice (WT), but not in KHK-KO mice, and that fructose stimulation increased NHE activity accompanied by a decrease in intracellular cAMP that is dependent on KHK. These results suggest that fructose metabolism by KHK is involved in the development of salt-sensitive hypertension through increases of renal sodium reabsorption by NHE3.

Free Research Field

腎臓内科学