2017 Fiscal Year Final Research Report
The role of NF-kB signal of pericytes in hypertensive renal injury
| Project/Area Number |
15K09283
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Asahikawa Medical College |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HASEBE Naoyuki 旭川医科大学, 医学部, 教授 (30192272)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 線維化 |
|---|
| Outline of Final Research Achievements |
The number of hypertensive patients in Japan is estimated to be around 43 million. Therefore, the supression of hypertensive organ damages are an extremely important issue. Capillary vessels are constructed from vascular endothelial cells and pericytes (Percytes: PCs). Thus, we focused on the transcription factor NF-kB signaling in PCs and successed the production of mice which overexpressed NF-kB signaling in Collagen 1a1 positive PCs.
We used angiotensin II load models as a hypertension model and found that no significant differences in kidney fibrosis between controls and NF-kb overexpressing mice, but a significant difference was observed in the fibrosis around the coronary artery of the heart between two groups. Finally, we confirmed the importance of NF-kb signaling in the fibrosis in hypertensive organ damages.
|
| Free Research Field |
腎臓内科
|
