Clinical evaluation of the hypothesis of CPP as a pathogen in chronic kidney disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09294
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Osaka City University
• Principal Investigator: Shoji Tetsuo 大阪市立大学, 大学院医学研究科, 准教授 (40271192)
• Co-Investigator(Kenkyū-buntansha): 森 克仁 大阪市立大学, 大学院医学研究科, 講師 (60382040) ; 絵本 正憲 大阪市立大学, 大学院医学研究科, 准教授 (90275248) ; 黒尾 誠 自治医科大学, 医学部, 教授 (10716864)
• Research Collaborator: NAKATANI Shinya ; UEDONO Hideki
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: リン毒性 / CKD-MBD / 心血管疾患 / 動脈硬化

Outline of Final Research Achievements

To evaluate the role of calci-protein particle (CPP) as a pathogen in chronic kidney disease, we measured serum concentration of CPP and T50, the latter being the time for CPP to transform in vitro to more cytotoxic form secondary CPP. Serum concentration of CPP was not increased in hemodialysis patients than healthy volunteers, and no correlation was found between CPP level and T50. In a cohort of hemodialysis patients, a shorter T50 predicted a higher risk of mortality, but CPP did not. These results support the hypothesis that CPP, following transformation in vivo, could play a pathological role in chronic kidney disease.

Free Research Field

腎臓病