The role of TET2 in mineralocorticoid receptor mediated transcription through epigenetic mechanisms and development of hypertension

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09296
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Keio University
• Principal Investigator: Kobayashi Sakiko 慶應義塾大学, 医学部(信濃町), 特任講師 (80383727)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ミネラルコルチコイド受容体 / 転写共役因子 / エピゲノム / 高血圧

Outline of Final Research Achievements

To elucidate the mechanisms of MR mediated transcription through epigenetic mechanisms, we decided to focus on one of demethylase, ten-eleven　translocation 2(TET2) among MR interacting proteins which were obtained in our MR-interacting protein-screening. Knock down of TET2 suppressed the transcriptional activation of MR target genes, SGK1 and ENaC, by aldosterone and it was suggested that TET2 transactivates MR mediated transcription. Other proteins related to epigenetic mechanisms which were obtained in our screening were also shown to control MR mediated transcription.

Free Research Field

内分泌内科