2017 Fiscal Year Final Research Report
The examination on the regression treatment for vascular calcification
| Project/Area Number |
15K09304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 血管石灰化 / 慢性腎臓病 / リン |
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| Outline of Final Research Achievements |
Phosphate load is the most important contributor for vascular calcification in chronic kidney disease. First of all, I explored the treatments which can suppress phosphate-induced calcification and osteoblastic trans-differentiation in vascular smooth muscle cells. I examined the inhibitory effects of a calcimimetic agent R568, sodium thiosulphate, etidronate, 25-hydroxyvitamin D, phosphate restriction and caloric restriction on phosphate-induced calcification and osteoblastic trans-differentiation in vascular smooth muscle cells. The administration of etidronate and phosphate restriction were most effective. However, their effects on the differentiation of monocyte to osteoclastic cell, which is necessary for absorption of calcification, were also suppressive. These results revealed it is difficult that calcification inhibitors, which I examined, regress vascular calcification. In future, the further exploration for candidates of calcification regressor is necessary.
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| Free Research Field |
CKD-MBD
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