The compensatory micro circulation regulation mechanism against cerebral perfusion pressure decrease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Mie University
• Principal Investigator: yata kenichiro 三重大学, 医学系研究科, 産学官連携研究員 (40467361)
• Co-Investigator(Kenkyū-buntansha): 及川 伸二 三重大学, 医学系研究科, 准教授 (10277006) ; 冨本 秀和 三重大学, 医学系研究科, 教授 (80324648)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脳灌流圧低下 / 代償性脳循環調節機構 / 二光子レーザー顕微鏡

Outline of Final Research Achievements

Cervical carotid artery bifurcation is a predilection site of the atherosclerosis, which is a major cause of cerebral infarction. There is a compensatory circulation regulation mechanism against cerebral perfusion pressure decrease. However, the detail mechanism occurring under hypoperfusion condition remains poorly understood. In this study, we performed in vivo imaging for bilateral common carotid artery occlusion mouse brain using Two-photon laser-scanning microscopy. We elucidated that vasodilatation occurred with peripheral artery under mild cerebral hypoperfusion condition. However, we admitted that vasoconstriction occurred with peripheral artery under severe cerebral hypoperfusion condition.

Free Research Field

神経内科学