• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2017 Fiscal Year Final Research Report

EEstablishment of treatment target for ALS / FTLD

Research Project

  • PDF
Project/Area Number 15K09323
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKeio University

Principal Investigator

Ito Daisuke  慶應義塾大学, 医学部(信濃町), 講師 (80286450)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywords筋萎縮性側策硬化症 / 前頭側頭葉変性症 / optineurin / ubiquilin2
Outline of Final Research Achievements

1) Two different molecules involved in familial ALS, UBQLN 2 and OPTN are both involved in endosomal vesicles involved in proteolysis, have the function of connecting enodosome and autopahgy, and formed a novel protein quality control mechanism in endosome. 2) In DRP (dipeptidere peat protein) by non-AUG (RAN) translation from abnormal elongation GGGGCC repetitive sequence, expression of poly-PR, which is strongly basic, significantly reduces gemini of coiled bodies and Cajal bodies into Hela cells and suggested that it reflects the pathology of ALS.

Free Research Field

神経内科

URL: 

Published: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi