2017 Fiscal Year Final Research Report
Elucidation of a mechanism of Lewy body formation
| Project/Area Number |
15K09327
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | パーキンソン病 / レビー小体 / アルファシヌクレイン / 脂質 / 細胞膜 |
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| Outline of Final Research Achievements |
Pathologically, Parkinson's disease (PD) is characterized by neuronal inclusions called Lewy bodies. Although the mechanism of Lewy body formation remains largely unknown, it is becoming clear that changes in the behavior of alpah-synuclein are critical in this process. alpha-Synuclein behaves differently depending on the lipid composition of membranes with which it interacts; therefore, one can postulate that the altered lipid composition of neuronal membranes may lead to Lewy body formation. The lipid composition of cellular membranes is consistently altered in the brains of patients with PD, and Lewy bodies are a common feature of several human lipidoses with mutations in enzymes that affect membrane lipids. This further supports the concept that alterations in the membrane lipids of neurons are central to Lewy body formation. Based on the working hypothsis, the present study revealed an altered lipid composition in brains of animal model of lipidosis.
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| Free Research Field |
脳神経内科
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