2017 Fiscal Year Final Research Report
Role of T cell dysregulation in neurodegenerative diseases
| Project/Area Number |
15K09338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Yokohama City University (2016-2017)
Nagoya University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | T細胞 / 神経変性疾患 / ミッドカイン |
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| Outline of Final Research Achievements |
We aimed to elucidate the role of Treg in neurodegenerative diseases using mouse models of Alzheimer’s disease and amyotrophic lateral sclerosis. First, we developed a mouse model using wild-type and midkine-KO mice by intraventricular injection of amyloidβ peptide (Aβ). The novel object recognition test revealed no significant improvement of cognitive deficit in Aβ-injected midkine-deficient mice, suggesting that this model represents acute Aβ-neurotoxicity and was not suitable to assess extraneuronal environment alteration. Next, we generated midkine-KO/SOD1-G93A-Tg mouse. This mouse model showed significant long survival accompanied by increases in circulating Treg. Pathological analysis demonstrated reduced motor neuron death with suppressed microglial activation in the lumbar spinal cord. This study suggested thatTreg enhancement by midkine inhibition is a potential therapeutic strategy against neurodegenerative diseases.
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| Free Research Field |
神経内科学
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