A cross-sectional study about circadian rhythm in Parkinson's disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09356
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Nara Medical University
• Principal Investigator: Kataoka Hiroshi 奈良県立医科大学, 医学部, 准教授 (30364061)
• Co-Investigator(Kenkyū-buntansha): 佐伯 圭吾 奈良県立医科大学, 医学部, 教授 (60364056) ; 刀根 庸浩 奈良県立医科大学, 医学部, 特任助手 (50630498)
• Research Collaborator: OBAYASHI Kenji 奈良県立医科大学, 医学部, 准教授 (30596656)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: パーキンソン病 / サーカディアンリズム / 客観的睡眠 / アクチグラフィ

Outline of Final Research Achievements

The prevalence of the sleep disturbance among patients of Parkinson disease (PD) is reported to be 40 to 60%, and it is the most common among non-motor symptoms of PD. Although a lot of studies showed lower subjective sleep quality in terms of difficulty in sleep maintenance and early awakening, evidence based on objectively measured sleep quality is limited. Recent study showed validity of sleep actigraphy among PD using optimal activity threshold to determine sleep/awake status. We conducted a cross-sectional study to compare objective sleep quality measured by actigraphy between general participants without PD, early stage PD, and late stage PD. We found significantly shorter total sleep time, lower sleep efficiency, longer wake after sleep onset, higher fragmentation index, and shorter sleep onset latency associated with progression of PD independent of potential confounders.

Free Research Field

脳神経内科学