2017 Fiscal Year Final Research Report
Nerve ageing and sarcopenia
| Project/Area Number |
15K09367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The Nukada Institute for Medical & Biological Research |
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Principal Investigator |
Nukada Hitoshi 公益財団法人額田医学生物学研究所, その他部局等, その他(移行) (60118833)
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| Co-Investigator(Kenkyū-buntansha) |
八木橋 操六 弘前大学, 医学研究科, 特任教授 (40111231)
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| Research Collaborator |
HOTTA Ryoutarou 公益財団法人額田医学生物学研究所 (50747897)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 末梢神経 / 加齢現象 / サルコペニア / Klotho マウス |
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| Outline of Final Research Achievements |
Peripheral nerve ageing has been studied in large myelinated nerve fibers. However, ageing of small myelinated and unmyelinated nerve fibers are unknown. We have found a loss of small nerve fibres in subjects over 85 y.o. using the new techniques of skin biopsy. We have also observed severe nerve atrophy of large nerve fibres in the accerelated ageing mouse model. These results suggested that small nerve fibres are affectd by ageing as well as large nerve fibres.
As the super-aging society approaches, the understanding of ageing including the peripheral nervous system, is a societal need.
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| Free Research Field |
神経内科
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