Functional elucidation of glucose sensing receptor: toward new understanding of glucose action

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09375
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Gunma University
• Principal Investigator: Nakagawa Yuko 群馬大学, 生体調節研究所, 助教 (90422500)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: グルコース / インスリン

Outline of Final Research Achievements

Glucose is the most important factor regulating insulin secretion, and its mechanism of action is still unknown. We have revealed that various intracellular second messengers are activated within only a few seconds of glucose stimulation in pancreatic β cells. Unlike the response via metabolism, this rapid response was not suppressed even in the presence of a metabolic inhibitor and could be reproduced with non-metabolic glucose analogs. Therefore, it is conceivable that a series of quick response is "a glucose metabolism-independent response". It also revealed that some of these signal responses are via T1R3 and Calcium Sensing Receptor.

Free Research Field

生理学