2017 Fiscal Year Final Research Report
New activation mechanism of brown adipocyte through CXCL12-CXCR4 pathway
Project/Area Number |
15K09376
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Chiba University |
Principal Investigator |
Ishikawa Ko 千葉大学, 医学部附属病院, 助教 (80456087)
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Research Collaborator |
KURITA Kenichi 千葉大学, 大学院医学研究院
TAKEDA Kenji 千葉大学, 大学院医学研究院
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | 褐色脂肪細胞 / 糖代謝 |
Outline of Final Research Achievements |
Brown adipocytes are organs that produce non-tremor thermogenesis using glucose or fatty acids as energy substrates. In this study, we clarified that CXCL12-CXCR4 is one of new brown adipocyte activating factors. Mice lacking CXCR4 specifically in brown adipocytes, exacerbated glucose metabolism when given a high fat diet. In addition, addition of CXCL 12 to brown adipose-cultured cells significantly increased UCP-1 and PGC-1a which are brown adipocyte activation markers, and fat saturation-related and increased fatty acid uptake genes were observed. Based on the above, the CXCL12-CXCR4 pathway is involved in brown adipose activation and may affect glucose metabolism in vivo.
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Free Research Field |
代謝内分泌
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