The role of protein tyrosine phosphatase-1B in the hypothalamic inflammation induced by a high fat diet

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Nagoya University
• Principal Investigator: Banno Ryoichi 名古屋大学, 医学系研究科, 講師 (80597865)
• Co-Investigator(Kenkyū-buntansha): 有馬 寛 名古屋大学, 医学系研究科, 教授 (50422770)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肥満 / 炎症 / グリア細胞

Outline of Final Research Achievements

Hypothalamus plays an important role in the regulation of energy balance. A high fat diet induces hypothalamic inflammation, which is known to play a causal role in obesity. We investigated the role of protein tyrosine phosphatase-1B（PTP1B), a regulator of leptin, insulin and inflammatory signaling, in the hypothalamic inflammation induced by a high fat diet. Our results suggest that PTP1B in the microglia enhances hypothalamic inflammation, and PTP1B in the astrocye increases body weight under a high fat diet conditions.

Free Research Field

医歯薬学　内科系臨床医学・代謝学