2017 Fiscal Year Final Research Report
Regulation of human beta cell mass
| Project/Area Number |
15K09399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Taketo 慶應義塾大学, 医学部, 講師 (60230463)
SATO Seiji 慶應義塾大学, 医学部, 助教 (90528762)
INAISHI Jun 慶應義塾大学, 医学部, 助教 (60724565)
MURAKAMI Rie 慶應義塾大学, 医学部, 助教 (40645719)
KITAGO Minoru 慶應義塾大学, 医学部, 講師 (70296599)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 糖尿病 / 2型糖尿病 / β細胞量 / 肥満 / 日本人 / 膵内分泌細胞 / 組織学 |
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| Outline of Final Research Achievements |
Aim of the study was to explore physiological and pathological regulations in beta cell mass in humans (Japanese). We have examined effects of obesity and diabetes on alpha and beta cell mass in humans and found a reduction in beta cell mass by 46% in Japanese patients with type 2 diabetes (Inaishi J et al. J Clin Endocrinol Metab 2016). Deleterious effects of pancreatic fat accumulation on beta cell has been shown in animal studies, which is postulated as a cause of type 2 diabetes development. By examining human pancreas, we have shown that intra-pancreatic fat accumulation has little effect on beta cell mass and glucose intolerance (Murakami R et al. J Clin Endocrinol Metab 2017).
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| Free Research Field |
内分泌代謝学
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