2017 Fiscal Year Final Research Report
The central regulatory mechanism of FGF21 on carbohydrate preference
| Project/Area Number |
15K09405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of the Ryukyus (2016-2017)
National Institute for Physiological Sciences (2015) |
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Principal Investigator |
Okamoto Shiki 琉球大学, 医学(系)研究科(研究院), 特命講師 (40342919)
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | FGF21 / 炭水化物嗜好性 / AMPK |
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| Outline of Final Research Achievements |
The activation of an AMPK in a subset of CRH-positive neurons in the paraventricular hypothalamus mediates the fasting-induced increase in high carbohydrate selection. The hepatokine, FGF21, modulates AMPK responsible CRH neurons directly. This mechanism might contribute the rapid recovery from the energy crisis in the starvation.
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| Free Research Field |
神経内分泌
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