Genomic and epigenomic regulations of metabolic syndrome related diseases.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09409
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: The University of Tokyo
• Principal Investigator: Shojima Nobuhiro 東京大学, 医学部附属病院, 特任准教授 (00447393)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖尿病 / メタボリックシンドローム

Outline of Final Research Achievements

Accumulation of adipose tissue cause insulin resistance and lead to metabolic syndrome and type 2 diabetes mellitus. Genomic changes in protein coding lesion of signaling molecules correlated to structural changes and disease severity. We analyzed epigenetic change in adipose tissue and found fat-specific epigenetic changes. Genetic and epigenetic regulations of protein structure and gene expressions are supposed to be important to disease progression. These findings may contribute to elucidate the molecular mechanisms of metabolic syndrome and type 2 diabetes mellitus.

Free Research Field

代謝