Development of therapeutic strategy against obesity-associated chronic inflammations based on the mechanism involved in sex-specific difference of Treg localization in adipose tissue.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: University of Toyama
• Principal Investigator: Wada Tsutomu 富山大学, 大学院医学薬学研究部(薬学), 講師 (00419334)
• Co-Investigator(Kenkyū-buntansha): 笹岡 利安 富山大学, 大学院医学薬学研究部(薬学), 教授 (00272906)
• Co-Investigator(Renkei-kenkyūsha): SAITO SHIGERU 富山大学, 大学院医学薬学研究部(医学), 教授 (30175351) ; SASAHARA MASAKIYO 富山大学, 大学院医学薬学研究部(医学), 教授 (20154015) ; SAMESHIMA AZUSA 富山大学, 附属病院, 助教 (80778465)
• Research Collaborator: ISHIKAWA AKARI ; ITO TETSUO ; IKURUMI MISA ; TANAKA TOMOKO
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Treg / 性差 / 代謝 / 慢性炎症

Outline of Final Research Achievements

Regulatory T cells (Treg) is known to attenuate obesity-associated chronic inflammation in the visceral adipose tissue. In contrast to the decreased of adipose Treg in male obese mice, we found that adipose Treg was increased in the visceral adipose tissue of female obese mice. Based on the fact, we constructed T cell specific estrogen receptor α deficient mouse (KO). Female KO mice showed a decrease of adipose Treg with mild exacerbation of chronic inflammation on high-fat diet or under condition with gestational diabetes, although the impact on glucose metabolism was not severe. In this study, we found several signals related to the localization of Treg in adipose tissue. These results shed a new insight for understanding of the fundamental knowledge for treatment of insulin resistance in obesity by the regulation of chronic inflammation in obese adipose tissue.

Free Research Field

代謝学