2017 Fiscal Year Final Research Report
An in vivo study to examine the roles of AMPK in bone formation by using osteoblast-specific AMPK knockout mice
| Project/Area Number |
15K09433
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Shimane University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
TAKENO AYUMU
NOTSU MASAKAZU
TANAKA KENICHIRO
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | AMPK / 骨芽細胞 / 骨細胞 / 骨形成 / 骨代謝 |
|---|
| Outline of Final Research Achievements |
The present study using osteoblast-specific AMPK knockout mice showed that deletion of osteoblast AMPK induced retardation of postnatal bone development, as well as reduction in trabecular and cortical bone volume, by decreasing osteoblast differentiation and increasing RANKL expression. These findings suggest that osteoblast AMPK plays important roles in bone modeling and remodeling. Accordingly, activation of osteoblast AMPK may be a candidate for treatment of osteoporosis with high bone turnover, as well as diabetes-related osteoporosis, although further studies are necessary to clarify the roles of AMPK in bone.
|
| Free Research Field |
内分泌代謝学
|
