Studies on thyroid autoimmunity: anti-mouse TSH receptor immune response and central tolerance in mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Nagasaki University
• Principal Investigator: NAGAYAMA Yuji 長崎大学, 原爆後障害医療研究所, 教授 (30274632)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 甲状腺 / 自己免疫 / バセドウ病 / TSH受容体 / マウスモデル

Outline of Final Research Achievements

Mice respond well to immunization with human thyrotropin receptor (TSHR), but not to immunization with mouse TSHR. We have previously found that peripheral immune tolerance plays a minor role in immune tolerance against mouse TSHR. The present studies was therefore designed to study a role for central tolerance in immune tolerance against mouse TSHR in BALB/c mice. By using deleton of thymic cells with anti-RANKL antibody and alos SKG mice which have a point mutation in ZAP-70 gene, we here clearly showed a significant role for central tolerance in immune tolerance against mouse TSHR in mice.

Free Research Field

内分泌学