2017 Fiscal Year Final Research Report
Identification of biological functions of granin-derived peptide NERP-4 on energy balance and glucose metabolism
| Project/Area Number |
15K09439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Research Collaborator |
三浦 綾子 宮崎大学, 医学部, 研究員 (70710903)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 生理活性ペプチド / 糖尿病 / インスリン / 膵β細胞 |
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| Outline of Final Research Achievements |
Neuroendocrine Regulatory Peptide-4 (NERP-4) was co-expressed with insulin in the pancreatic β cells of human, mice and rat. Ca2+ imaging analyses showed that NERP-4 accelerated intracellular Ca2+ influx in MIN6 cells. NERP-4 potentiated glucose-stimulated insulin secretion (GSIS) from isolated mouse islets. Peripheral administration of NERP-4 increased plasma insulin level under glucose load in rats. NERP-4 is a novel regulator of GSIS.
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| Free Research Field |
医歯薬学
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