The molecular mechanism of sarcopenia associated with male menopause

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09441
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Fukui Michiaki 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30247829)
• Co-Investigator(Kenkyū-buntansha): 山崎 真裕 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50309134) ; 田中 武兵 京都府立医科大学, 医学(系)研究科(研究院), 助教 (70713717) ; 濱口 真英 京都府立医科大学, 医学部附属病院, 研究員 (80350883)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Sarcopenia / Muscle atrophy / Diabetes / Glucose metabolism / Metabolic syndrome / Androgen / Testosterone

Outline of Final Research Achievements

Sarcopenia has been thought to be a diabetic complication. Sarcopenia occurs during male menopause, and it is a risk for diabetes. However, the molecular mechanism of sarcopenia caused by reduced androgen signal has not been clarified yet.
We established a murine model for male menopause sarcopenia and performed a transcriptome analysis. Scid1 and smox were identified as mRNAs at low expression level in the atrophic soleus muscle. The expression level of mir23b-3p was upregulated in the atrophic muscle. We revealed that mir23b-3p could repress pten and could upregulate muscle protein synthesis.

Free Research Field

糖尿病学