2017 Fiscal Year Final Research Report
RAGE of adrenocortical cell accelerates corticosterone production in mice
| Project/Area Number |
15K09443
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小山 英則 兵庫医科大学, 医学部, 教授 (80301852)
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| Research Collaborator |
MONDEN Masayo
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | RAGE / 副腎皮質 / コルチコステロン / 炎症 / LPS |
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| Outline of Final Research Achievements |
In this study, we examined the involvement of receptor for advanced glycation end products (RAGE) in hypothalamic-pituitary-adrenal axis.
In vivo, adrenal gland of Ager -/- mice was significantly heavier than that of Ager +/+ mice though without significant differences in body weight. Histological examination showed that RAGE was exclusively expressed in adrenocortical cells, and that adrenocortical cells in Ager -/- mice exhibited hypertrophic change as compared with those in Ager +/+ mice. The amount of corticosterone in 24-hour urine in Ager -/- mice was significantly less than that in Ager +/+ mice. Changes in serum corticosterone concentration following lipopolysaccharide (LPS) injection serum corticosterone concentration of Ager -/- mice were significantly lower than those of Ager +/+ mice. In vitro, RAGE expressed in adrenocortical cell appears to accelerate LPS-induced corticosterone production in mouse, where ERK 1/2 MAP kinase signaling may partly play a role.
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| Free Research Field |
医学
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