2017 Fiscal Year Final Research Report
Novel molecular mechanism of maintenance of stemness through a DNA methylation regulator in normal and malignant hematopoiesis
| Project/Area Number |
15K09452
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Mie University |
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Principal Investigator |
Ono Ryoichi 三重大学, 医学系研究科, 講師 (40422414)
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| Co-Investigator(Renkei-kenkyūsha) |
NOSAKA TETSUYA 三重大学, 大学院医学系研究科, 教授 (30218309)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 白血病 |
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| Outline of Final Research Achievements |
Recently, emerging evidence has revealed the important role of epigenetic regulation of gene expression. In the present study, I analyzed molecular mechanism of maintenance of stemness in normal and malignant hematopoiesis through a DNA methylation regulator, in which little was still known about its function. Molecular and biological analysis of several new mouse models of leukemia using conditional ablation and inducible expression of the regulator highlighted an interesting characteristic closely associated with malignant hematopoiesis, which had not been elucidated yet. Currently, I am investigating this property extensively.
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| Free Research Field |
血液内科学
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