Targeting of bone marrow mesenchymal stromal/stem cells for the treatment of B cell acute lymphoblastic leukemia

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09453
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Kyoto University
• Principal Investigator: MIURA Yasuo 京都大学, 医学研究科, 助教 (70605146)
• Research Collaborator: IWASA Masaki 滋賀医科大学, 消化器血液内科, 大学院生 ; FUJISHIRO Aya 滋賀医科大学, 消化器血液内科, 大学院生 ; FUJII Sumie 京都大学, 血液・腫瘍内科, 大学院生
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 急性リンパ性白血病 / 間葉系間質細胞 / 抗がん剤抵抗性 / 細胞接着 / 骨髄微小環境 / 間葉系幹細胞

Outline of Final Research Achievements

Adult B cell acute lymphoblastic leukemia (B-ALL) belongs to an entity of intractable hematological diseases. In this study, we found that human B-ALL cells that adhered to human bone marrow mesenchymal stromal/stem cells (BM-MSC) showed resistance to anti-cancer drugs. Proteasome inhibitors interfered with the adhesion of B-ALL cells to BM-MSCs and subsequently restored chemosensitivity of B-ALL cells. In B-ALL mouse model, chemotherapy with bortezomib-containing anti-cancer drugs prolonged the survival of the mice. These findings suggest that pharmacological targeting of BM-MSCs is effective for the treatment of patients with B-ALL.

Free Research Field

細胞治療学